Article

Designing artificial cells to harness the biological ion concentration gradient.

Department of Chemical Engineering, Yale University, New Haven, Connecticut 06520, USA.
Nature Nanotechnology (impact factor: 27.27). 12/2008; 3(11):666-70. DOI:10.1038/nnano.2008.274 pp.666-70
Source: PubMed

ABSTRACT Cell membranes contain numerous nanoscale conductors in the form of ion channels and ion pumps that work together to form ion concentration gradients across the membrane to trigger the release of an action potential. It seems natural to ask if artificial cells can be built to use ion transport as effectively as natural cells. Here we report a mathematical calculation of the conversion of ion concentration gradients into action potentials across different nanoscale conductors in a model electrogenic cell (electrocyte) of an electric eel. Using the parameters extracted from the numerical model, we designed an artificial cell based on an optimized selection of conductors. The resulting cell is similar to the electrocyte but has higher power output density and greater energy conversion efficiency. We suggest methods for producing these artificial cells that could potentially be used to power medical implants and other tiny devices.

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    Journal of Physics Condensed Matter 08/2010; 22(31):315301. · 2.55 Impact Factor
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Keywords

action potential
 
action potentials
 
Cell membranes
 
different nanoscale conductors
 
electric eel
 
electrocyte
 
form ion concentration gradients
 
higher power output density
 
ion concentration gradients
 
ion pumps
 
model electrogenic cell
 
natural cells
 
numerous nanoscale conductors
 
optimized selection
 
tiny devices
 

Jian Xu