Oxidative stress early in pregnancy and pregnancy outcome

Department of Surgery, University of Medicine and Dentistry of New Jersey-SOM, Stratford, NJ 08084, USA.
Free Radical Research (Impact Factor: 2.99). 11/2008; 42(10):841-8. DOI: 10.1080/10715760802510069
Source: PubMed

ABSTRACT The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF(2alpha) (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

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