Article

[Effect of Kuijieling decoction on proteins expression of IKK-alpha in colonic mucosa of ulcerative colitis model rats].

Pi-wei institute, Guangzhou University of TCM, Guangzhou 510405, China.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 07/2008; 31(7):1016-8. pp.1016-8
Source: PubMed

ABSTRACT To explore the changes of protein expression of IKK-alpha as well as the effects of Kuijieling Decoction (KD) on colonic mucosa of ulcerative colitis (UC) model rats.
UC model rats were induced by TNBS. The rats were randomly divided into six groups: normal control (NC) group, model control (MC) group, Kuijieling low dose (KLD), middle dose (KMD) group, high dose (KHD) group and SASP group. After 10-days' treatment the rats were killed to get their colonic tissues. The positive rate of IKK-alpha expression was detected by immunohistochemical (IHC).
The positive rate of IKK-alpha in MC group was significantly higher than that in NC group (P < 0.01). The positive rate of IKK-alpha in KMD group was significantly lower than that in MC group (P < 0.05). The positive rate of IKK-alpha in KHD and SASP group were significantly lower than that in MC group (P < 0.01).
IKK-alpha may be involved in the pathogenesis of UC, and KD can inhibit positive rate of IKK-alpha in colonic mucosa of UC model rats induced by TNBS. The inhibitory effects of KD on UC may be associated with this.

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Keywords

10-days' treatment
 
colonic mucosa
 
colonic tissues
 
IKK-alpha expression
 
inhibitory effects
 
KMD
 
KMD group
 
Kuijieling Decoction
 
Kuijieling low dose
 
MC group
 
middle dose
 
model control
 
NC group
 
normal control
 
positive rate
 
protein expression
 
SASP group
 
UC model rats
 
UC model rats induced
 
ulcerative colitis