Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings.

Warwick Medical School, Clinical Science Research Institute, University Hospital -Coventry, CV2 2DX, UK.
Diabetes & Vascular Disease Research (Impact Factor: 3.04). 12/2008; 5(4):260-8. DOI: 10.3132/dvdr.2008.038
Source: PubMed

ABSTRACT High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.

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