Article

Diagnostic shifts in ALS? From clinical specter to imaging spectra

From the Florey Institute for Neuroscience and Mental Health (A.B.), University of Melbourne, Melbourne
Neurology (Impact Factor: 8.3). 01/2013; 80(7). DOI: 10.1212/WNL.0b013e318281cd27
Source: PubMed

ABSTRACT Paradigm shifts are occurring across the realm of amyotrophic lateral sclerosis (ALS). In the past, we instructed medical students that ALS was solely a clinical diagnosis; that careful clinical examination raised the specter of this devastating condition, and neurophysiologic testing provided confirmation. We taught that ALS was an isolated clinical syndrome; that neuroimaging was not helpful for the diagnosis, other than to exclude mimic syndromes; that patients did not have significant dementia; and finally, that little could be done to predict or alter an individual patient's course.

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