Quality of life of subjects with cancers in Ibadan, Nigeria.
ABSTRACT Background: Cancer is associated with psychological and physical morbidities. The presence of such comorbidities has been reported to worsen the overall outcome and quality of life (QOL) of affected people. Aims: To assess the QOL and its determinants among participants with cancer. Methods: We administered the short version of the World Health Organization Quality of Life-BREF instrument, socio-demographic/clinical data collection sheet and structured clinical interview for Diagnostic and Statistical Manual Fourth Edition (DSM-IV) diagnosis to 210 consecutively admitted participants with cancer at the University College Hospital Ibadan to determine the diagnosis of major depression. Results: The sample consisted of 63 men and 147 women; 68 participants had cancer of the breast, while 59, 40 and 43 had cancers of the cervix, colon/rectum and prostate, respectively. The QOL of most of the participants was fair. Approximately 30% of the participants were depressed, 75.7% had pains while 49.5% of them had advanced cancer. Male sex, older age, depression, pains and advanced stage cancers were significantly associated with poor QOL. Conclusion: The QOL of participants is negatively affected by male sex, older age, depression, advanced stage of cancer and pains.
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ABSTRACT: Objective: The aim of the current study was to evaluate changes in treatment outcomes in terms of health- related quality of life (HRQoL) and symptom burden at zero, one, three, and six months after an initial diagnosis of colorectal cancer. The demographic and clinical characteristics that account for outcome changes in patients were investigated using a repeated measures framework. Methods and Materials: A cohort study was performed of 134 colorectal cancer patients followed from diagnosis to 6 months post-treatment in Central Taiwan. HRQoL and symptoms were assessed at diagnosis and one, three, and six months thereafter. The Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire, VAS pain, and the Memorial Symptom Assessment Scale (MSAS) were used for data collection. A generalized estimating equation (GEE) was applied for statistical analysis. Results: The majority of the patients were male (55%) and married (91.5%). The mean age was 60.4 years (SD = 11.71). Most were diagnosed stage III and IV colorectal cancer (54.5%). All underwent surgery; some also received chemotherapy (CT) or concurrent chemoradiation therapy (CCRT). The results of the GEE showed that overall, the HRQoL, pain, and symptoms of the patients significantly improved over the treatment period. Patients with stage IV disease who had received surgery and CCRT showed the worst HRQoL. Females, patients with comorbidity, and stage IV patients had higher pain scores over time. Female and stage IV patients had more severe physical symptoms, whereas stage II and IV patients had worse psychological symptoms over time. Conclusion: The patients' HRQoL, pain, and symptoms significantly improved over the 6-month treatment period. Certain patient and clinical variables accounted for changes in treatment outcomes regarding HRQoL and symptom burden in colorectal cancer patients.Asian Pacific journal of cancer prevention: APJCP 03/2013; 14(3):1905-9. · 1.50 Impact Factor