Article

Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells.

Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Immunity (impact factor: 21.64). 11/2008; 29(5):795-806. DOI:10.1016/j.immuni.2008.08.013 pp.795-806
Source: PubMed

ABSTRACT To initiate an adaptive immune response, rare antigen-specific naive CD4(+) T cells must interact with equally rare dendritic cells (DCs) bearing cognate peptide-major histocompatibility complex (MHC) complexes. Lymph nodes (LNs) draining the site of antigen entry are populated by lymphoid-resident DCs as well as DCs that have immigrated from tissues, although the requirement for each population in initiating the T cell response remains unclear. Here, we show that antigen processing and presentation by both lymphoid-resident and migratory DCs was required for clonal selection and expansion of CD4(+) T cells after subcutaneous immunization. Early antigen presentation by lymphoid-resident DCs initiated activation and trapping of antigen-specific T cells in the draining LN, without sufficing for clonal expansion. Migratory DCs, however, interacted with the CD4(+) T cells retained in the LN to induce proliferation. Therefore, distinct DC subsets cooperate to alert and trap the appropriate cell and then license its expansion and differentiation.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

activation
 
adaptive immune response
 
antigen-specific T cells
 
clonal expansion
 
clonal selection
 
DCs
 
distinct DC subsets
 
draining LN
 
immigrated
 
induce proliferation
 
initiating
 
LNs
 
lymphoid-resident
 
lymphoid-resident DCs
 
Migratory DCs
 
rare antigen-specific naive CD4(+)
 
rare dendritic cells
 
subcutaneous immunization
 
T cell response
 
trapping
 

Eric J Allenspach