Article

The spectrum of nonmotor symptoms in early Parkinson disease

and Cambridge Centre for Brain Repair (R.A.B.), Cambridge University, Cambridge, UK.
Neurology (Impact Factor: 8.3). 01/2013; 80(3):276-81. DOI: 10.1212/WNL.0b013e31827deb74
Source: PubMed

ABSTRACT Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD.
A total of 159 patients with early PD and 99 healthy controls participated in this study. NMS were screened for using the Nonmotor Symptom Questionnaire. Other assessments included measures of motor disability (Movement Disorders Society-revised Unified Parkinson's Disease Rating Scale [MDS-UPDRS]), disease severity (Hoehn & Yahr staging), depression (Geriatric Depression Scale), and global cognitive function (Mini-Mental State Examination and Montreal Cognitive Assessment).
The PD group reported a significantly greater number of NMS compared with controls (8.4 [4.3] vs 2.8 [2.6]). In the PD group, the most commonly experienced NMS were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation. Patients with higher MDS-UPDRS III scores and those with the postural instability gait subtype experienced a greater number of NMS.
NMS are common in early PD and reflect the multisystem nature of the disorder. Even in the earliest stages of PD, NMS may be detrimental to patients' functional status and sense of well-being.

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    • "of Cognitive Impairment in Cohorts with Longitudinal Evaluation—Parkinson's disease) conducted between June 2009 and December 2011 [29] "
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    04/2015; DOI:10.1109/JBHI.2015.2419317
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    • "However, the fact that NMS may arise as part of drug related effects and side effects confounds this issue further. Recently, the importance of measuring NMS using validated tools, such as the NMS Questionnaire (NMSQuest) [6] and the NMS Scale (NMSS) [7] has been described in two independent case control studies in drug na¨ıve PD [8] and early PD [9] patients. "
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    Journal of Parkinson's Disease 06/2014; 4(3). DOI:10.3233/JPD-140372 · 1.10 Impact Factor
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    • "from more than one population-based or cohort study ? Evidence from one population-based or cohort study ± No evidence from population-based or cohort studies, but respective non-motor symptom is frequently seen in early PD (Erro et al. 2013; Khoo et al. 2013; Barone et al. 2009) RBD rapid eye movement sleep behavior disorder, PLMS periodic limb movements during sleep, RLS restless legs syndrome Need to redefine Parkinson's disease REM sleep behavior disorder RBD is a parasomnia clinically characterized by dreamenacting behaviors related to loss of physiological atonia during REM sleep (Schenck et al. 1986). The prevalence of ''idiopathic'' RBD in the population is not well defined and a commonly cited figure of 0.4 % may well be an underestimate (Gagnon et al. 2006). "
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    Journal of Neural Transmission 05/2013; 120(S1). DOI:10.1007/s00702-013-1038-5 · 2.87 Impact Factor
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