Idiopathic hand osteoarthritis vs haemochromatosis arthropathy-a clinical, functional and radiographic study

2nd Department of Paediatrics, Medical Faculty, Comenius University, Bratislava, Slovakia, Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Department of Internal Medicine, Hospital Oberndorf, Oberndorf and Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.
Rheumatology (Oxford, England) (Impact Factor: 4.48). 01/2013; 52(5). DOI: 10.1093/rheumatology/kes392
Source: PubMed


Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.

In total, 299 patients (141 with HH arthropathy of the hands and 158 patients with idiopathic HOA) were recruited. Structured clinical assessment including hand function tests, as well as hand radiographs with scoring according to Kellgren-Lawrence, were carried out in all patients.

HH arthropathy and HOA differed significantly: patients with HH arthropathy were younger and predominantly male as compared with HOA. In males but not females, HH arthropathy led to an earlier start of symptoms than in HOA. Patients with HOA had more tender joints and worse hand function than patients with HH arthropathy, although subjective measures of joint pain and function were similar. MCP and wrist joint involvement was more frequent and severe in HH arthropathy, while HOA patients more frequently had degenerative changes in the first CMC as well as PIP and DIP joints.

HH arthropathy and idiopathic HOA differ significantly in terms of epidemiology, localization, severity of symptoms and radiographic changes.

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Available from: Tomas Dallos, Oct 13, 2014
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