[Show abstract][Hide abstract] ABSTRACT: Brentuximab vedotin (BV) is an anti-CD30 monoclonal antibody conjugated with the cytotoxic drug monomethylyauristatin E (MMAE), a potent microtubule inhibitor. In re-lapsed/refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma, BV achieved durable response with low and transitory toxicity. Accordingly, it was approved by FDA in 2011 for patients affected by these malignancies. In some case reports, BV obtained rapid response in CD30-expressing cutaneous T-cell lymphoma, as transformed mycosis fungoides and relapsed/refractory primary cutaneous ACL lymphoma. Currently, two phase 2 trials are ongoing to assess the potential use of brentuximab in patients af-fected by refractory/relapsed CD30+ T-cell lymphoproliferative disorders and in patients affected by mycosis fungoides/Sézary syndrome, respectively. Finally, one phase 3 trial is comparing brentuximab to methotrexate or bexarotene in CD30-expressing cutaneous T-cell lymphomas. Among the several new drugs tested in the last 5 years, BV showed the most promising and challenging results to be translated in the clinical practice.
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