Role of Platelets in Neurodegenerative Diseases: A Universal Pathophysiology.

All India Institute of Medical Sciences, Neurology , Ansari Nagar, New Delhi , 110029 India.
The International journal of neuroscience (Impact Factor: 1.53). 01/2013; DOI: 10.3109/00207454.2012.751534
Source: PubMed

ABSTRACT Abstract Platelets play an important role in a variety of disorders viz; cardiovascular, psychosomatic, psychiatric, thrombosis, HIV/AIDS in addition to various neurodegenerative diseases (NDD). Recent evidence indicates that platelet react to diverse stressors thereby offering an interesting vantage point for understanding their potential role in contemporary medical research. This review addresses the possible role of platelets as a systemic probe in various NDD's such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease (PD), Huntington's Disease (HD), Alzheimer's Disease (AD), Multiple Sclerosis (MS) etc. The current review based on published literature, describes a probable link between platelets and pathophysiology of various NDD's. It also discusses how platelets epitomize ultra structural, morphological, biochemical and molecular changes, highlighting their emerging role as systemic tools in different NDD's.

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