This study investigated the effect of curcumin (0.05-g/100-g diet) supplementation on a high-fat diet (10% coconut oil, 0.2% cholesterol, wt/wt) fed to hamsters, one of the rodent species that are most closely related to humans in lipid metabolism. Curcumin significantly lowered the levels of free fatty acid, total cholesterol, triglyceride, and leptin and the homeostasis model assessment of insulin resistance index, whereas it elevated the levels of high-density lipoprotein cholesterol and apolipoprotein (apo) A-I and paraoxonase activity in plasma, compared with the control group. The levels of hepatic cholesterol and triglyceride were also lower in the curcumin group than in the control group. In the liver, fatty acid beta-oxidation activity was significantly higher in the curcumin group than in the control group, whereas fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and acyl coenzyme A:cholesterol acyltransferase activities were significantly lower. Curcumin significantly lowered the lipid peroxide levels in the erythrocyte and liver compared with the control group. These results indicate that curcumin exhibits an obvious hypolipidemic effect by increasing plasma paraoxonase activity, ratios of high-density lipoprotein cholesterol to total cholesterol and of apo A-I to apo B, and hepatic fatty acid oxidation activity with simultaneous inhibition of hepatic fatty acid and cholesterol biosynthesis in high-fat-fed hamsters.
"iwayomogi is frequently used to treat 'dampness and phlegm' in TKM, and also exerts effects against hyperlipidemia and obesity (Choi et al., 2013; Han et al., 2012). Another herb, Curcuma longa radix, the therapeutic and anti-hyperlipidemic properties of which are well-documented, has been used to cure pathological 'blood stasis' (Jang et al., 2008; Manjunatha and Srinivasan, 2007; Yiu et al., 2011). TKM practitioners typically use two or more herbs in combination to enhance therapeutic efficacy; in our previous study, the combination of A. iwayomogi and C. longa (ACE) exhibited anti-atherosclerotic activity in an apoE knockout mouse model (Shin et al., 2014). "
"This result was consistent with previous findings. It has been reported that curcumin lowers TG and FFA levels in high-fat-fed hamsters  and this hypolipidemic property may be the reason for the reduction in body weight. As shown in previous studies, curcumin has a beneficial role in improving insulin resistance and lowering blood glucose in db/db mice through the elevation of plasma insulin levels, which enhances the activation of glycolysis and inhibits gluconeogenesis . "
"In mice that were chronically administered alcohol, the increased hepatic MDA levels were also decreased following curcumin treatment (Lee et al. 2013). In another study, the elevated hepatic and erythrocyte thiobarbituric acid reactive substances (TBARS) in hamsters fed an HFD were reported to be reduced with curcumin supplementation (Jang et al 2008). In the study of He et al. (2012) using HFD-fed mice, they reported increased levels of muscular ROS and MDA. "
[Show abstract][Hide abstract] ABSTRACT: High fat diet (HFD) is associated with oxidative stress induced fatty liver. Curcumin, an extract of Curcuma longa, has been shown to possess potent antioxidant and hypolipidemic properties. In this study, we investigated the effect of curcumin treatment on hepatic heme oxygenase-1 (HO-1) expression along with pro-oxidant-antioxidant status and lipid accumulation in rats fed an HFD. Male Sprague-Dawley rats were distributed among 4 groups: Group 1, which was fed the control diet (10% of total calories from fat); Group 2, which was fed the HFD (60% of total calories from fat); and groups 3 and 4, which received the HFD supplemented with curcumin and the control diet supplemented with curcumin (1 g/kg diet; w/w), respectively, for 16 weeks. HFD caused increases in hepatic lipid levels, production of reactive oxygen species, and lipid peroxidation. Further, HO-1 expression was significantly decreased. Histopathological examination showed hepatic fat accumulation and slight fibrotic changes. Curcumin treatment reduced hepatic lipids and oxidative stress parameters, and HO-1 expression was significantly increased. These findings suggest that increased HO-1 expression, along with suppressed oxidative stress as well as reduced hepatic fat accumulation and fibrotic changes, contribute to the beneficial effects of curcumin in attenuating the pathogenesis of fatty liver induced metabolic diseases.
Canadian Journal of Physiology and Pharmacology 08/2014; 92(10):1-8. DOI:10.1139/cjpp-2014-0174 · 1.77 Impact Factor
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