Article

Stereological evaluation of volumetric asymmetry in healthy human cerebellum.

Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Surgical and Radiologic Anatomy (impact factor: 1.06). 10/2008; 31(3):177-81. DOI:10.1007/s00276-008-0424-4
Source: PubMed

ABSTRACT Age-related volumetric differences in brain anatomy or volumetric brain analyses in many disorders are of interest. Delineating the normal anatomical cerebellar volume is of importance for both the anatomists and clinicians. In the present study, we aimed to evaluate the cerebellar volume using a stereological technique and to determine the possible volumetric asymmetry depending on age and gender.
Volumetric asymmetry of cerebellar hemispheres was evaluated using stereological method on the magnetic resonance images (MRI) of healthy male and female subjects. Randomly selected individuals (27 males, 27 females) aged between 10-86 years who have normal brain MRI were enclosed in the study. All the subjects were right handed. The individuals were divided into three groups according to age as 18-34 (young), 35-60 (middle aged) and 60-84 (elder) and their MRI images were analyzed. The data set were analyzed by two factor repeated measure analysis.
Although the cerebellum was smaller between young and middle aged groups and also middle aged and elder groups, there were no any statistically significant differences between compared groups' mean (P > 0.05). There were not statistically differences according to sex and age groups (P > 0.05).
There was no cerebellar asymmetry between compared groups. The stereological evaluation of cerebellar asymmetry in humans correlate with both gender and age groups is of importance for both clinicians and anatomists. The technique is simple, reliable, unbiased and inexpensive.

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    Article: The volume fraction of brain ventricles to total brain volume: a computed tomography stereological study.
    I Akdogan, Y Kiroglu, S Onur, N Karabuluti
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    ABSTRACT: This study has been designed to estimate the volume fraction of the brain ventricles volume to total brain volume and to correlate them with gender and age in normal subjects. Cranial computed tomography (CT) images of 80 normally evaluated subjects (five female and five male for each decade) were selected from 1,073 CT examinations. The volumes of total brain, cerebral aqueduct, fourth, third, and lateral ventricles and their ratios were estimated using the Cavalieri method and volume fraction-stereological methods. The ratio of total brain ventricle volume to total brain volume was comparable between the two genders (p > 0.05, independent t test). Mean volume fraction of total ventricle volume to total brain volume was found to be 1.21% in the first and 3.37% in the last decades. Mean volume fraction was found to increase significantly with age (p < 0.01, r = 0.630, Pearson). In conclusion, the mean percentage of total ventricle volume within the total brain volume was found to be 2%. We demonstrated the volume fraction of total ventricle to total brain in normal subjects. Total ventricle volume to total brain volume fractions can be important tools in determining ventricle volumes, which denote variability in some diseases (Alzheimer, schizophrenia, neurodegenerative disorders, etc.) and can be estimated by stereological methods.
    Folia morphologica 11/2010; 69(4):193-200. · 0.52 Impact Factor
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Keywords

27 females
 
age groups
 
Age-related volumetric differences
 
brain anatomy
 
cerebellar asymmetry
 
cerebellar hemispheres
 
cerebellar volume
 
female subjects
 
healthy male
 
humans correlate
 
magnetic resonance images
 
measure analysis
 
MRI images
 
normal anatomical cerebellar volume
 
possible volumetric asymmetry
 
stereological evaluation
 
stereological method
 
stereological technique
 
Volumetric asymmetry
 
volumetric brain analyses