DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Transplant Infectious Disease (Impact Factor: 1.98). 12/2012; 15(1). DOI: 10.1111/tid.12045
Source: PubMed

ABSTRACT Parainfluenza virus (PIV) may cause life-threatening pneumonia in lung transplant patients and there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, to treat severe PIV type 3 pneumonia in a lung transplant patient. Treatment was well tolerated and associated with improvement in oxygenation and symptoms, along with rapid clearance of PIV. DAS181 should be systematically evaluated for treatment of PIV infection in transplant recipients.

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