Trauma Profile in Egyptian Adolescents With First-Episode Schizophrenia

*Department of Psychiatry, Faculty of Medicine, Zagazig University, Zagazig, Egypt
The Journal of nervous and mental disease (Impact Factor: 1.69). 01/2013; 201(1):23-9. DOI: 10.1097/NMD.0b013e31827ab268
Source: PubMed


We aimed to investigate the relation of trauma profile to schizophrenia psychopathology in a sample of Egyptian drug-naïve adolescent patients with first-episode schizophrenia. In addition, a hypothesized mediating effect of brain-derived neurotrophic factor (BDNF) in this relation was formally tested. We assessed 74 eligible outpatients using the Positive and Negative Syndrome Scale (PANSS) for measuring psychopathology. Trauma histories were recorded with the help of the Cumulative Trauma Measure. Serum BDNF levels were estimated by enzyme-linked immunosorbent assay. Total cumulative trauma, personal identity trauma, and survival trauma were found to be the significant predictors for schizophrenia psychopathology. BDNF fully mediated the associations between total cumulative trauma and overall schizophrenia psychopathology. BDNF also mediated the associations between some types of trauma and both PANSS-positive and PANSS-negative symptom factors. We concluded that total cumulative trauma and certain trauma types are linked with schizophrenia psychopathology. BDNF appears to mediate these links.

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    • "Abandonment, sexual abuse, and physical abuse are other forms of Type II trauma (Terr, 1991). Type I traumas, on the other hand, involve exposure to a singular traumatic event (e.g., car accident), and Type III traumas involve exposure to micro-or macroaggressive acts that are continuous and ongoing (e.g., racial and gender discrimination; Kira, 2001; Kira, Fawzi, & Fawzi, 2013; Kira, Lewandowski, Templin, Ramaswamy, Ozkan, et al., 2008; Kira, Smith, Lewandowski, & Templin, 2010). Bullying might be best classified as a personal identity Type II trauma; however, it is rarely conceptualized or identified in the literature as a type of traumatic stress. "
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