Association between monosodium glutamate intake and sleep-disordered breathing among Chinese adults with normal body weight

Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: .
Nutrition (Impact Factor: 3.05). 12/2012; 29(3). DOI: 10.1016/j.nut.2012.08.011
Source: PubMed

ABSTRACT OBJECTIVE: To assess whether monosodium glutamate (MSG) intake is associated with sleep-disordered breathing (SDB). METHODS: Data from 1227 Chinese subjects who participated in the Jiangsu Nutrition Study were analyzed. All the participants were examined at two time points (baseline in 2002 and follow-up in 2007). The MSG intake was assessed quantitatively in 2002 and a sleep questionnaire was used to assess snoring and to construct an SDB probability score in 2007. Those within the fifth quintile of the score (highest) were defined as having a high probability of SDB. RESULTS: The MSG intake was positively associated with snoring and a high probability of SDB in participants who had a normal body weight but in those who were overweight. A comparison of the extreme quartiles of MSG intake in subjects with a body mass index lower than 23 kg/m(2) showed an odds ratio of 2.02 (95% confidence interval 1.02-4.00) for snoring and an odds ratio of 3.11 (95% confidence interval 1.10-8.84) for a high probability of SDB. There was a joint effect between MSG and overweight in relation to SDB. CONCLUSION: The intake of MSG may increase the risk of SDB in Chinese adults with a normal body weight.