Vitamin D deficiency: A forgotten treatable cause of motor delay and proximal myopathy

Pediatric Neurology, Pediatric Subspecialties Service, Geneva Children's Hospital, Switzerland. Electronic address: .
Brain & development (Impact Factor: 1.88). 12/2012; 36(1). DOI: 10.1016/j.braindev.2012.11.014
Source: PubMed


We report a four-year-old African boy referred for proximal muscle weakness, fatigability and episodic limb pain. Classical causes of structural and metabolic myopathy were initially considered before clinical and biological features of vitamin D deficiency rickets were identified. Prompt treatment with vitamin D and calcium supplementation led to a complete reversal of the muscle symptoms. Rickets-associated myopathy should be included in the differential diagnosis of proximal myopathy, especially in at-risk individuals. Vitamin D deficiency and its prevention remain important health issues in industrialized countries.

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