Update on nutrients involved in maintaining healthy bone

Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona di Pavia, Pavia, Italy. Electronic address: .
Endocrinología y Nutrición 12/2012; 60(4). DOI: 10.1016/j.endonu.2012.09.006
Source: PubMed


Osteoporosis is a leading cause of morbidity and mortality in the elderly and influences quality of life, as well as life expectancy. Currently, there is a growing interest among the medical scientists in search of specific nutrients and/or bioactive compounds of natural origin for the prevention of disease and maintenance of bone health. Although calcium and vitamin D have been the primary focus of nutritional prevention of osteoporosis, a recent research has clarified the importance of several additional nutrients and food constituents. Based on this review of the literature, supplementation with vitamins B, C, K, and silicon could be recommended for proper maintenance of bone health, although further clinical studies are needed. The results of studies on long-chain polyunsaturated fatty acids, potassium, magnesium, copper, selenium, and strontium are not conclusive, although studies in vitro and in animal models are interesting and promising.

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    • "It has been documented that the regular intake of these vitamins B prevents brain shrinkage, and the resulting dementia, among persons with a high homocysteine concentration in blood (Douaud et al., 2013), whereas folate intake below the recommended daily allowance was associated with increased risk of cognitive impairment (Agnew-Blais et al., 2015). Homocysteine concentration was inversely related with the concentration of vitamins B and bone density (Ebesunun et al., 2014; Enneman et al., 2014), and vitamin B supplementation may be part of a strategy to maintain bone health (Rondanelli et al., 2013). "
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