Article

Multiple myeloma : recent progress in diagnosis and treatment.

Internal Medicine, Niigata Cancer Center Hospital.
Journal of Clinical and Experimental Hematopathology 01/2012; 52(3):149-59. DOI: 10.3960/jslrt.52.149
Source: PubMed

ABSTRACT Multiple myeloma (MM) has been the most intractable hematological disease for many years. Recently, basic and clinical research has advanced remarkably and a new therapeutic strategy has been established. The introduction of high-dose melphalan with autologous stem-cell transplantation and the availability of molecular-targeted novel agents such as immunomodulatory drugs and proteasome inhibitors have dramatically changed the treatment strategies for MM. Achievement of a high response rate resulted in the extension of overall survival, but further research and the development of more multimodality therapeutic approaches is warranted to cure this disease. [J Clin Exp Hematopathol 52(3) : 149-159, 2012].

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