Reed's syndrome or familial leiomyomatosis cutis et uteri is an autosomal dominant disorder, characterized by multiple cutaneous and uterine leiomyomas. We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological examination, imaging, and past medical records, a diagnosis of Reed's syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity.
[Show abstract][Hide abstract] ABSTRACT: Cutaneous leiomyomas are uncommon, benign smooth muscle tumors originating from the arrector pili muscle of the hair follicle that are frequently unrecognized and underdiagnosed by clinicians. They sometimes coexist with common uterine fibroids in an inherited disorder named multiple cutaneous and uterine leiomyomatosis, also referred to as Reed's syndrome. We report a case of Reed's syndrome in a young woman who had been misdiagnosed for many years.
Case Reports in Dermatology 05/2014; 6(2):189-93. DOI:10.1159/000365862
[Show abstract][Hide abstract] ABSTRACT: Background:
Cutaneous mosaicism is a possible cause of segmental skin diseases. Cutaneous leiomyomatosis represent a spectrum of conditions ranging from single lesions to disseminated wide distribution. Reed's syndrome, is an autosomal dominant disorder characterized by multiple cutaneous and uterine leiomyomas.
We observed a segmental cutaneous piloleimyomatosis type 1 in a 55-year old female who had an uterus extirpation because of uterine leiomyomas. The cutaneous lesions were moderately painful and localized on her left upper trunk. They presented as firm nodules and small plaques in a linear arrangement. Renal cancer was excluded.
In patients with multiple cutaneous (pilo)leiomyomas a search for underlying systemic diseases is necessary in order to not miss benign or malignant tumors of internal organs.
Journal of Dermatological Case Reports 09/2014; 8(3):67-9. DOI:10.3315/jdcr.2014.1178
[Show abstract][Hide abstract] ABSTRACT: Cutaneous leiomyomas are firm, round to oval, skin-coloured to brownish papules and
nodules that may present as a solitary, few discrete or multiple clustered lesions. They are divided
into three types, namely, piloleiomyoma, dartoic leiomyoma and angioleiomyoma. Here, we report
a case of a 32-year-old man who presented to us with multiple painful nodules over different parts
of his body. Based on the histopathological examination, imaging, and past medical records, a diagnosis
of multipl leiomyomatosis was made. Multipl leiomyomas may be associated with Reed's
syndrome, polycythemia, and renal cell carcinoma. Therefore, necessary examinations and investigations
should be carried out in patients with multiple leiomyomas.
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