Farmacia (Impact Factor: 1.25). 01/2012; 60(1):92-101.

ABSTRACT Indapamide (IDP) is a non-thiazide sulphonamide diuretic drug, currently used for the treatment of essential hypertension. A pharmaceutical formulation is considered appropriate when no interactions drug-excipient or excipient-excipient occur.
The purpose of the present work was to study the compatibility of IDP with the pharmaceutical excipients employed in immediate release tablets preformulations (2.5mg/cp), by using thermoanalytical techniques differential scanning calorimetry (DSC) and thermogravimetry (TG)) with the support of X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR).
In this respect, thermal analysis (DSC, TG), XRPD and FTIR methods were employed to evaluate the behaviour of IDP and excipients used in formulation (lactose monohydrate, microcrystalline cellulose, sodium amidonglycolate, polyvinylpyrrolidone, colloidal silicon dioxide (aerosil), magnesium stearate), but also its corresponding physical binary mixtures.
FTIR, thermal analysis (DSC, TG) and XRDP methods applied to the mentioned physical mixtures did not show evidence of interactions in the solid state.
Based on these results supplied by FTIR, DSC/TG and XRPD, all the excipients were found to be compatible with IDP, so they can be further used in the formulation of immediate release tablets.

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    ABSTRACT: The interaction study of naproxen with aluminium hydroxide has been carried out in both solid state and wet state. Naproxen was co-milled in the solid state and colyophilized after overnight wet equilibration in different weight ratios. Physicochemical characterization of the interaction was carried out using analytical techniques such as Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and Scanning electron microscopy (SEM) studies. In vitro dissolution studies were also performed to examine the effect of interaction on dissolution. FTIR spectra suggested an acid–base interaction between the carboxylic acid containing naproxen and aluminium hydroxide. DSC thermogram confirmed the absence of complexation between naproxenaluminium hydroxide and SEM study indicated the presence of stabilized microparticles containing cluster of nano- and submicron drug crystals associated with aluminium hydroxide. In vitro dissolution studies revealed the improved release of naproxen from formulated powder samples
    Farmacia 01/2013; 61(1):103-115. · 1.25 Impact Factor
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    ABSTRACT: The main aim in the development of a pharmaceutical system is the achievement of an adequate preparation. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature, the stability and bioavailability of the drugs and, consequently, their therapeutic efficacy and safety. We present the thermal and spectroscopic study of drug/polymer physical mixtures containing ibuprofen (IB), clindamycin hydrochloride (CD), metronidazole (MZ), as the active pharmaceutical ingredient (API) and hydroxypropyl methylcellulose (HPMC K100M), Poloxamer 407, polyethylene oxide (PEO 1105) and polycarbophil (Noveon AA1) as excipients, defined as prototype formula. Differential scanning colorimetry (DSC) analysis revealed the deplacement of the characteristic peaks for the prototype formulas of excipients in the case of IB and CD. A Fourier transform infrared spectroscopy (FT-IR) technique was used to confirm and to investigate the type of the possible interactions between the components. In both cases, the spectroscopic data revealed that weak intermolecular hydrogen-bond type interaction is incriminated, involving the carbonyl moiety of IB and in a lower extent the hydroxyl group of CD. The analysed excipients did not show any effect on the MZ.
    Farmacia 07/2013; 61(4):703-712. · 1.25 Impact Factor


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May 29, 2014