Association study of the Fyn gene with schizophrenia in the Chinese-Han population

aDepartment of Psychiatry, The First Affiliated Hospital bDepartment of Scientific Research and Subject Construction, Shengjing Hospital, China Medical University cShenyang Mental Health Center, Shenyang, China.
Psychiatric genetics (Impact Factor: 1.94). 02/2013; 23(1):39-40. DOI: 10.1097/YPG.0b013e328358640b
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Available from: Gang Zhu, Sep 25, 2014
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    • "The relationship among suicide, violence, and schizophrenia (Rogers and Fahy, 2008) and the characteristics comparison of suicide attempters and non-attempters with schizophrenia in a rural community (Ran et al., 2005; Isjanovski et al., 2010) was still researched. Some previous literature reported the relationship between schizophrenia and the gene (Guan et al., 2013; Hu et al., 2013; Wu et al., 2013; Yang et al., 2013) in Chinese populations. The studies on the socio-demographic and clinical characteristics of schizophrenia still have been reported in China (Yan et al., 2013; Zhang et al., 2013a, 2014). "
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    ABSTRACT: Background There has been much literature on schizophrenia, but very little is known about the characteristics of suicides with schizophrenia in comparison with the suicides with other diagnosed psychiatric disorders and without psychiatric disorders. Methods Thirty-eight suicides with schizophrenia, 150 suicides with other psychiatric disorder, and 204 suicides without a psychiatric disorder were entered in current study. Psychological autopsy (PA) was applied to collect information of the suicides. Social demographic factors and clinical characteristics of the suicides were measured. The well validated standard scales were applied: Beck Hopelessness Scale (BHS), Landerman's Social Support Scale (DSSI), Dickman's Impulsivity Inventory (DII), Spielberger State-Trait Anxiety Inventory (STAI) and Hamilton Depression Scale (HAMD). Suicide intents were appraised by the Beck Suicide Intent Scale (SIS). The SCID based on the Diagnostic and Statistical Manual of Mental Disorders—IV (DSM-IV) was applied to assess the psychiatric status of individuals. Demographic characteristics, clinical characteristics, method of suicide and suicide intents of suicides were compared among the three groups (schizophrenia group, other psychiatric disorders group, and none psychiatric disorders group). Results There were 9.7% of suicides who suffered schizophrenia. The current study found that being female was the risk factor for suicides with schizophrenia in rural China, which was opposite to the previous studies. The suicides with psychiatric disorder scored higher on hopelessness, anxiety, and depression, but lower on social support and impulsivity than suicides without psychiatric disorder. The suicides with psychiatric disorder were less impulsive than none psychiatric disorders group, too. The schizophrenia group did not show more violence than other psychiatric disorders group. Conclusions This research compared the demographic characteristics, clinical characteristics, method of suicide and suicide intents among the suicides with schizophrenia, with other diagnosed psychiatric disorder and without psychiatric disorders. The result indicated that each groups showed their unique characteristics, which gave us new viewpoints to control and prevent the prevalence of suicides according to their different characteristics.
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    ABSTRACT: Although several genome-wide association (GWA) studies of human personality have been recently published, genetic variants that are highly associated with certain personality traits remain unknown, due to difficulty reproducing results. To further investigate these genetic variants, we assessed biological pathways using GWA datasets. Pathway analysis using GWA data was performed on 1,089 Korean women whose personality traits were measured with the Revised NEO Personality Inventory for the five-factor model of personality. A total of 1,042 pathways containing 8,297 genes were included in our study. Of these, 14 pathways were highly enriched with association signals that were validated in 1,490 independent samples. These pathways include association of: Neuroticism with axon guidance [L1 cell adhesion molecule (L1CAM) interactions]; Extraversion with neuronal system and voltage-gated potassium channels; Agreeableness with L1CAM interaction, neurotransmitter receptor binding, and downstream transmission in postsynaptic cells; and Conscientiousness with the interferon-gamma and platelet-derived growth factor receptor beta polypeptide pathways. Several genes that contribute to top-ranked pathways in this study were previously identified in GWA studies or by pathway analysis in schizophrenia or other neuropsychiatric disorders. Here we report the first pathway analysis of all five personality traits. Importantly, our analysis identified novel pathways that contribute to understanding the etiology of personality traits. This article is protected by copyright. All rights reserved.
    Genes Brain and Behavior 03/2015; 14(4). DOI:10.1111/gbb.12212 · 3.66 Impact Factor