Motion-Compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention

Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
Biomedical Optics Express (Impact Factor: 3.65). 12/2012; 3(12):3105-18. DOI: 10.1364/BOE.3.003105
Source: PubMed


A motion-compensated, hand-held, common-path, Fourier-domain optical coherence tomography imaging probe has been developed for image-guided intervention during microsurgery. A hand-held prototype instrument was achieved by integrating an imaging fiber probe inside a stainless steel needle and attached to the ceramic shaft of a piezoelectric motor housed in an aluminum handle. The fiber probe obtains A-scan images. The distance information was extracted from the A-scans to track the sample surface distance and a fixed distance was maintained by a feedback motor control which effectively compensated hand tremor and target movements in the axial direction. Real-time data acquisition, processing, motion compensation, and image visualization and saving were implemented on a custom CPU-GPU hybrid architecture. We performed 10× zero padding to the raw spectrum to obtain 0.16 µm position accuracy with a compensation rate of 460 Hz. The root-mean-square error of hand-held distance variation from target position was measured to be 2.93 µm. We used a cross-correlation maximization-based shift correction algorithm for topology correction. To validate the system, we performed free-hand OCT M-scan imaging using various samples.

Download full-text


Available from: Yong Huang, Feb 25, 2014
28 Reads
  • Source
    • "Nevertheless its application as a potential sensor for intraoperative tool control is fairly new [7–9]. We have recently presented a novel microsurgical tool platform, SMART (Smart Micromanipulation Aided Robotic-surgery Tool) and have demonstrated its ability to cancel a surgeon’s physiological tremor [10] and to stabilize a handheld imaging probe [11]. SMART instruments utilize common path, swept source optical coherence tomography (CP SS-OCT) in closed loop with a piezoelectric motor based feedback control system. "
    [Show abstract] [Hide abstract]
    ABSTRACT: A handheld Smart Micromanipulation Aided Robotic-surgery Tool (SMART) micro-forceps guided by a fiber-optic common-path optical coherence tomography (CP-OCT) sensor is presented. A fiber-optic CP-OCT distance and motion sensor is integrated into the shaft of a micro-forceps. The tool tip position is manipulated longitudinally through a closed loop control using a piezoelectric motor. This novel forceps design could significantly enhance safety, efficiency and surgical outcomes. The basic grasping and peeling functions of the micro-forceps are evaluated in dry phantoms and in a biological tissue model. As compared to freehand use, targeted grasping and peeling performance assisted by active tremor compensation, significantly improves micro-forceps user performance.
    Biomedical Optics Express 07/2013; 4(7):1045-1050. DOI:10.1364/BOE.4.001045 · 3.65 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Several main directions approached in optical coherence tomography in the last 5 years are presented.
    2011 ICO International Conference on Information Photonics (IP); 05/2011
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Optical coherence tomography (OCT) has a tremendous global impact upon the ability to diagnose, treat, and monitor eye diseases. A miniature 25-gauge forward-imaging OCT probe with a disposable tip was developed for real-time intraoperative ocular imaging of posterior pole and peripheral structures to improve vitreoretinal surgery. The scanning range was 2 mm when the probe tip was held 3-4 mm from the tissue surface. The axial resolution was 4-6 µm and the lateral resolution was 25-35 µm. The probe was used to image cellophane tape and multiple ocular structures.
    Biomedical Optics Express 08/2013; 4(8):1342-50. DOI:10.1364/BOE.4.001342 · 3.65 Impact Factor
Show more