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Structure and biological functions of IL-31 and IL-31 receptors

Division of Medical Cell Biology, College of Life Sciences, Sichuan University, Chengdu, PR China.
Cytokine & growth factor reviews (Impact Factor: 6.54). 11/2008; 19(5-6):347-56. DOI: 10.1016/j.cytogfr.2008.08.003
Source: PubMed

ABSTRACT Interleukin-31, produced mainly by activated CD4(+) T cells, is a newly discovered member of the gp130/IL-6 cytokine family. Unlike all the other family members, IL-31 does not engage gp130. Its receptor heterodimer consists of a unique gp130-like receptor chain IL-31RA, and the receptor subunit OSMRbeta that is shared with another family member oncostatin M (OSM). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways. IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, causing inflammatory bowel disease, airway hypersensitivity and dermatitis. This review summarizes the recent findings on the biological characterization and physiological roles of IL-31 and its receptors.

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    • "Recent studies have shown that IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRß). IL-31 might be involved in controlling keratinocyte differentiation and proliferation and also has a number of effects that point to a role in the regulation of immune responses in skin [8] [11]. "
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    BioMed Research International 06/2014; 2014:653724. DOI:10.1155/2014/653724 · 2.71 Impact Factor
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    • "Several studies have reported associations with SCS/CM with genetic markers on chromosome 20 (Sodeland et al., 2011; Meredith et al., 2012; Sahana et al., 2013) with many of them overlapping or nearby the regions detected in this study. Nevertheless, a number of possible candidate genes have been identified including the IL31Rα gene which acts as part of a receptor complex for the IL-31 cytokine in the activation of signaling pathways including the JAK-STAT and MAPK pathways which can initiate a wide range of immunological processes (Zhang et al., 2008; Cornelissen et al., 2012). The detection of a QTL region in close proximity to a number of genes of the complement system also looks promising given the importance of the complement system in both host innate and adaptive immunity. "
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    • "IL6-type cytokines are a family of cytokines including IL6, IL11, LIF, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT1) and cardiotrophin-like cytokine (CLC) (Heinrich et al., 2003). Two newly discovered cytokines have recently been added to this family: IL31 and IL27 (Dillon et al., 2004; Zhang et al., 2008). IL6 family cytokines characteristically have both pro-and anti-inflammatory properties, and members are all major players in the regulation of the acute phase response and immune response (Heinrich et al., 2003). "
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