Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807
ABSTRACT Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F-18]-T807.
New England Journal of Medicine 03/2015; 372(12):1151-62. DOI:10.1056/NEJMcpc1409839 · 54.42 Impact Factor
Frontiers in Neurology 03/2015; 6:38. DOI:10.3389/fneur.2015.00038
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ABSTRACT: Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that develops as a result of repetitive mild traumatic brain injury. Chronic traumatic encephalopathy is characterized by a unique pattern of accumulation of hyperphosphorylated tau in neurons and astrocytes. The tau abnormalities begin focally and perivascularly at the depths of the cerebral sulci, spread to the superficial layers of the adjacent cortex, and eventually become widespread throughout the medial temporal lobes, diencephalon, and brainstem. Abnormalities in 43 kDa TAR DNA-binding protein are also found in most cases of CTE. To date, CTE can only be diagnosed by postmortem neuropathological examination, although there are many ongoing research studies examining imaging techniques and biomarkers that might prove to have diagnostic utility. Currently, the incidence and prevalence of CTE are unknown, although great strides are being made to better understand the clinical symptoms and signs of CTE. Further research is critically needed to better identify the genetic and environmental risk factors for CTE as well as potential rehabilitation and therapeutic strategies. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Seminars in Neurology 02/2015; 35(1):20-28. DOI:10.1055/s-0035-1545080 · 1.78 Impact Factor