Article

Probiotics as the potential biotherapeutics in the management of Type 2 Diabetes -Prospects and Perspectives.

Molecular Biology Unit, Dairy Microbiology Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
Diabetes/Metabolism Research and Reviews (Impact Factor: 3.59). 02/2013; 29(2). DOI: 10.1002/dmrr.2376
Source: PubMed

ABSTRACT Diabetes Mellitus is a looming epidemic worldwide, affecting almost all the major sections of the society causing burden on global health and economy. A large number of studies have identified a series of multiple risk factors such as genetic predisposition, epigenetic changes, unhealthy life style, altered gut microbiota that causes increased adiposity, β cell dysfunction, hyperglycemia, hypercholesterolemia, adiposity, dyslipidaemia, metabolic endotoxemia, systemic inflammation, intestinal permeability (leaky gut), defective incretins secretion, oxidative stress associated with T2D as a multifactorial disorder. Recent studies have proposed multi-factorial interventions including dietary manipulation in the management of T2D and are also recommended by many national and international diabetes associations. These studies are aimed at deciphering the Gut microbial influence on health and disease. Interestingly, results from several genomic, metagenomic and metabolomic studies have provided substantial information to target gut microbiota by dietary interventions for the management of T2D. Probiotics particularly lactobacilli and bifidobacteria have recently emerged as the prospective biotherapeutics with proven efficacy demonstrated in various in vitro and in vivo animal models adequately supported with their established multifunctional roles and mechanism of action for the prevention and disease treatment. The dietary interventions in conjunction with probiotics - a novel multifactorial strategy to abrogate progression and development of diabetes holds considerable promise through improving the altered gut microbial composition and by targeting all the possible risk factors. This review will highlight the new developments in probiotic interventions and future prospects for exploring probiotic therapy in the prevention and control of life style diseases like T2D. Copyright © 2012 John Wiley & Sons, Ltd.

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Available from: Sunita Grover, Aug 12, 2014
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