Low nutrient intake among adult women and patients with severe tuberculosis disease in Uganda: a cross-sectional study

BMC Public Health (Impact Factor: 2.32). 12/2012; 12(1):1050. DOI: 10.1186/1471-2458-12-1050
Source: PubMed

ABSTRACT Background
Information regarding dietary nutrient intake during tuberculosis disease is lacking. We established the relationship between disease severity or wasting during pulmonary tuberculosis and nutrient intake.

In a cross-sectional study of 131 adults with or without pulmonary tuberculosis were screened for human immune-deficiency virus (HIV), wasting, disease severity using 13 item validated clinical TBscore, and 24-hour dietary intake recall.

Of the 131 participants, 61 were males and 70 females. Overall men and women had similar age. In average 24-hour nutrient intake, the following nutrients: energy, protein, total fat, carbohydrate, calcium, vitamin A, and folate were low among patients with severe tuberculosis disease. Patients with moderate-to-severe clinical TBscore had lower average energy intake than patients with mild TBscores (6.11 vs. 9.27 MJ, respectively) (p<0.05). The average 24-hour nutrient intakes between wasted and non-wasted tuberculosis patients were comparable. Nutrient intake among men was higher when compared to women regardless of wasting and severity of tuberculosis. Among those with wasting, men had higher average energy intake than women (8.87 vs. 5.81 MJ, respectively) (p<0.05). Among patients with mild disease, men had higher average energy intake than women with mild disease (12.83 vs. 7.49 kcal, respectively) (p<0.001).

Findings suggest that severity of pulmonary tuberculosis and female gender had reduced nutrient intake. Early tuberculosis diagnosis and nutritional support may be important in management of tuberculosis patients.

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    • "The relationship between malnutrition and infection, especially in TB, is well established [1e5]. Evidence suggests that malnutrition, particularly low body mass index (BMI), can lead to secondary immune dysfunction that increases the host's susceptibility to infections [1] [3] [5] [6]. Body weight changes during treatment have been explored as a simple biomarker for both disease severity and treatment outcomes [4] [7]. "
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    Clinical nutrition (Edinburgh, Scotland) 02/2015; DOI:10.1016/j.clnu.2015.02.007 · 3.94 Impact Factor
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    • "Nutrition and nutritional status are also important factors in TB-related outcomes (Jaganath and Mupere, 2012; Mupere et al., 2012a). We have shown that nutritional status of a patient may be an indicator on how the food basket is shared in the household and the subsequent macro-and micronutrient intake (Mupere et al., 2012b). Because of the shared environmental and genetic components of diet and obesity (or in the case of TB, malnutrition), the HHC design provides a robust setting to test the role of nutritional status on infectious disease outcomes. "
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    Frontiers in Genetics 04/2013; 4:61. DOI:10.3389/fgene.2013.00061
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    PLoS ONE 11/2013; 8(11):e79940. DOI:10.1371/journal.pone.0079940 · 3.53 Impact Factor
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