Article

Onset of late posttraumatic seizure after dehydroepiandrosterone treatment.

Internal Medicine Department, Soroka University Medical Center, Beer-Sheva, Israel.
Fertility and sterility (Impact Factor: 4.59). 11/2008; 91(3):931.e1-2. DOI: 10.1016/j.fertnstert.2008.08.115
Source: PubMed

ABSTRACT To describe the first reported case of a seizure in a patient using the dietary supplement DHEA in an attempt to improve ovarian oocyte production.
Case report.
University-affiliated teaching hospital, neurologic department.
A 30-year-old woman with fragile X syndrome and no history of any convulsive disorder who was receiving IVF treatment.
Daily treatment with the dietary supplement DHEA.
Generalized seizure.
After 1 month of DHEA treatment, the patient was admitted with a generalized seizure.
A generalized seizure, associated with concurrent intake of DHEA.

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    • "7-keto DHEA would also have a distinct advantage over DHEA as a treatment for alcohol abuse and dependence in that it does not act as a precursor for the sex hormones (Lardy et al., 1998) and would be free of the adverse effects associated with increased production of testosterone and estradiol (Panjari and Davis, 2007). Furthermore, unlike the sulfated form of DHEA (DHEA-S) (Ticku and Kulkarni, 1988) and the negative modulator RO15-4513 (Karp et al., 2009), there is very little evidence that DHEA (Heuser et al., 1965) or 7-keto DHEA are proconvulsant unless administered in large concentrations directly into the brain. In contrast, RO15-4513 has been shown to be convulsant in rats at relatively high doses, and a study by Miczek and Weerts (1987) found that small doses of this compound (1 mg/kg) in primates produced overt seizure-related behaviors (e.g., tremors) including a fatal tonic-clonic seizure in one subject. "
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