Hepatoprotective and antiviral functions of silymarin components in HCV infection.

Departments of Laboratory Medicine, University of Washington, Seattle, WA
Hepatology (Impact Factor: 11.06). 03/2013; 57(3). DOI: 10.1002/hep.26179
Source: PubMed
1 Follower
18 Reads
    • "Its antiviral effectiveness against Hepatitis B and especially Hepatitis C viruses is well defined. However, there are limited data about its antibacterial activity (Gordon et al. 2006; Tamayo and Diamond 2007; Wagoner et al. 2010; Polyak et al. 2013; Wei et al. 2013). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Limited treatment options in infectious diseases caused by resistant microorganisms created the need to search new approaches. Several herbal extracts are studied for their enormous therapeutic potential. Silymarin extract, from Silybum marianum (milk thistle), is an old and a new remedy for this goal. The purpose of this study is to evaluate the antibacterial and antiadherent effects of silymarin besides biofilm viability activity on standard bacterial strains. Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherent/antibiofilm activity, and effects on biofilm viability of silymarin were evaluated against standard bacterial strains. MIC values were observed between 60 and >241 μg/mL (0.25->1 mmol/L). Gram-positive bacteria were inhibited at concentrations between 60 and 120 μg/mL. Gram-negative bacteria were not inhibited by the silymarin concentrations included in this study. MBC values for Gram-positive bacteria were greater than 241 μg/mL. Adherence/biofilm formations were decreased to 15 μg/mL silymarin concentration when compared with silymarin-untreated group. Silymarin reduced the biofilm viabilities to 13 and 46 % at 1 and 0.5 mmol/L concentrations, respectively. We demonstrated that silymarin shows antibacterial and antiadherent/antibiofilm activity against certain standard bacterial strains which may be beneficial when used as a dietary supplement or a drug.
    Folia Microbiologica 05/2015; 60(4). DOI:10.1007/s12223-015-0399-6 · 1.00 Impact Factor
  • Source
    • "It is moderately absorbed (23-47%) at the gastrointestinal tract. The maximum plasma concentration is achieved at 1-2h after oral dosing of milk thistle extract in human (Polyak et al., 2013). Silymarin is primarily excreted through the bile while some are cleared via the kidneys with a clearance half-life of 6-8 hours. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent outbreaks of highly pathogenic and occasional drug-resistant influenza strains have highlighted the need to develop novel anti-influenza therapeutics. Here we report computational and experimental efforts to identify influenza neuraminidase inhibitors from among the 3000 natural compounds in the Malaysian-Plants Natural-Product (NADI) database. These 3000 compounds were first docked into the neuraminidase active site. The five plants with the largest number of top predicted ligands were selected for experimental evaluation. Twelve specific compounds isolated from these five plants were shown to inhibit neuraminidase, including two compounds with IC50 values less than 92 μM. Furthermore, four of the twelve isolated compounds had also been identified in the top 100 compounds from the virtual screen. Together, these results suggest an effective new approach for identifying bioactive plant species that will further the identification of new pharmacologically active compounds from diverse natural-product resources.
    Journal of Chemical Information and Modeling 01/2015; 55(2). DOI:10.1021/ci500405g · 3.74 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: An estimated 170 million people worldwide are chronically infected with the Hepatitis C Virus (HCV), which is characterized histologically by a persistent immune and inflammatory response that fails to clear HCV from hepatocytes. This response is recruited to the liver in part by the chemokine CXCL10, the serum and intrahepatic levels of which have been inversely linked to the outcome of interferon (IFN)-based therapies for hepatitis C. Bystander tissue damage from this ineffective response is thought to lead to increased hepatocyte turnover and the development of fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). However, CXCL10 is traditionally viewed as an orchestrator of the angiostatic and anti-tumor immune response. In this review, we will explore this duality and the pathways by which CXCL10 is produced by hepatocytes during HCV infection, its effects on resident and infiltrating immune cells, and how deregulation of these cell populations within the liver may lead to chronic liver inflammation. We will also discuss potential host-directed therapies to slow or reverse HCV-induced inflammation that leads to fibrosis, cirrhosis, and HCC.
    Clinical Cancer Research 01/2013; 19(6). DOI:10.1158/1078-0432.CCR-12-0928 · 8.72 Impact Factor
Show more