Remodeling a tissue: Subtraction adds insight
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.Science Signaling (Impact Factor: 6.28). 11/2012; 5(252):pe52. DOI: 10.1126/scisignal.2003620
Sculpting a body plan requires both patterning of gene expression and translating that pattern into morphogenesis. Developmental biologists have made remarkable strides in understanding gene expression patterning, but despite a long history of fascination with the mechanics of morphogenesis, knowledge of how patterned gene expression drives the emergence of even simple shapes and forms has grown at a slower pace. The successful merging of approaches from cell biology, developmental biology, imaging, engineering, and mathematical and computational sciences is now accelerating progress toward a fuller and better integrated understanding of the forces shaping morphogenesis.
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