Article

Can Exercise Teach Us How to Treat Heart Disease?

Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, CLS-9, Boston, MA 02215. .
Circulation (Impact Factor: 14.95). 11/2012; 126(22):2625-35. DOI: 10.1161/CIRCULATIONAHA.111.060376
Source: PubMed
1 Follower
 · 
188 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The benefit of exercise training in congestive heart failure (CHF) has become widely appreciated over the past 20 years. It is now clear that exercise exerts a number of beneficial effects in CHF, including an improvement of skeletal muscle perfusion, and metabolism, breathing efficiency, and neurohumoral activation [1]. More recent evidence indicates that exercise training in patients with CHF also improves cardiac function [2], which is in agreement with observations in animal models of CHF and appears mediated by exercise-induced amelioration of CHF-associated interstitial fibrosis and cardiomyocyte dysfunction and apoptosis [3]. These beneficial effects of exercise are the consequence of the activation of different molecular signalling pathways that drive the transcriptional control of cardiac remodelling in exercise training versus CHF [1, 3, 4].In this issue of the Netherlands Heart Journal the Dutch Royal Society for Physiotherapy (KNGF) presents practical guidelines for exercis ...
    Netherlands heart journal: monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 12/2014; 23(1). DOI:10.1007/s12471-014-0637-6 · 2.26 Impact Factor
  • Journal of the American College of Cardiology 09/2014; 64(12):1267-9. DOI:10.1016/j.jacc.2014.04.082 · 15.34 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Exercise has long been considered an essential element for sustaining cardiovascular health. A vast literature of clinical studies suggests that exercise serves as an effective intervention for the primary and secondary prevention of cardiovascular disease, although the optimal nature, intensity, and duration of exercise for maximizing these cardiovascular benefits remain unclear. On a molecular level, exercise induces physiologic growth of the heart primarily by driving cardiomyocyte hypertrophy, notably through the interconnected IGF-1-PI3K-AKT1 and C/EBPβ-CITED4 pathways. Here, we explore the range of clinical evidence supporting the cardiovascular benefits of exercise and outline the molecular pathways that play major roles in regulating these protective effects.
    Trends in Cardiovascular Medicine 12/2014; DOI:10.1016/j.tcm.2014.12.014 · 2.07 Impact Factor