"The health benefits of physical activity and exercise are well recognized (Hawley et al., 2014; Mann and Rosenzweig, 2012; Voss et al., 2013). Exercise is the first line of therapy for various metabolic diseases like diabetes and obesity, but exercise also improves outcomes in diseases involving other tissues, such as the heart and brain. "
"In cardiac hypertrophy associated with pathological processes, it has been shown that CSCs participate in the reparative processes (Ellison et al., 2013; Leri et al., 2005); however, extensive damage cannot be completely reversed, indicating that the regenerative potential of these stem cells during a damage challenge is limited (Chan et al., 2009; Hatzistergos et al., 2010B; Bailey et al., 2009). For the physiological cardiac hypertrophy observed in exercise training (Waring et al., 2014; Xiao et al., 2014b), pregnancy (Xiao et al., 2014a) or postnatal growth (Mann and Rosenzweig, 2012), little is known about the role of resident CSCs. Waring et al. (2014) have demonstrated that c-Kit + CSCs play an active role during physiological cardiac hypertrophy in mice specifically for exercise training. "
"The metabolic, cardiovascular, autonomic, and anti-inflammatory benefits of a physically active life style have led many researchers to suggest exercise training (ET) as an important nonpharmacological tool in the prevention and treatment of CVD [7–11]. The effectiveness of ET as a great tool in the treatment of patients with established CAD (either with or without MI) has been widely reported in the literature [7, 12–16]. "
[Show abstract][Hide abstract] ABSTRACT: The cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides a significant increase in mortality rate, and seems to precede metabolic, hormonal, and immunological changes. Moreover, the reduction in the parasympathetic function has been associated with inflammatory response in different pathological conditions. Over the years, most of the studies have indicated the exercise training (ET) as an important nonpharmacological tool in the management of autonomic dysfunction and reduction in inflammatory profile after a myocardial infarction. In this work, we reviewed the effects of ET on autonomic imbalance after MI, and its consequences, particularly, in the post-MI inflammatory profile. Clinical and experimental evidence regarding relationship between alterations in autonomic regulation and local or systemic inflammation response after MI were also discussed.
Mediators of Inflammation 06/2014; 2014:702473. DOI:10.1155/2014/702473 · 3.24 Impact Factor
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