A Mediator Lost in the War on Cancer

Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: .
Cell (Impact Factor: 32.24). 11/2012; 151(5):927-9. DOI: 10.1016/j.cell.2012.11.003
Source: PubMed


An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor β (TGF-β) signaling. Inhibition of the TGF-β pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.

10 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: Uterine fibroids are common, benign tumors that cause considerable morbidity. Insights into the biologic and genetic mechanisms underlying these tumors at the cellular level are pointing the way to novel treatment approaches. Uterine fibroids (leiomyomas) represent the most common tumor in women. These lesions disrupt the functions of the uterus and cause excessive uterine bleeding, anemia, defective implantation of an embryo, recurrent pregnancy loss, preterm labor, obstruction of labor, pelvic discomfort, and urinary incontinence and may mimic or mask malignant tumors. By the time they reach 50 years of age, nearly 70% of white women and more than 80% of black women will have had at least one fibroid; severe symptoms develop in 15 to 30% of these women.(1),(2) Uterine fibroids in black women are significantly larger at diagnosis than those ...
    New England Journal of Medicine 10/2013; 369(14):1344-1355. DOI:10.1056/NEJMra1209993 · 55.87 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND Human leiomyomata (fibroids) are benign tumors of the uterus, represent the most common neoplasms of reproductive-aged women and have a prevalence of ∼70% in the general population. This disorder conveys a significant degree of morbidity and remains the leading indication for hysterectomy in the USA. Prior investigations of aberrant microRNA (miRNA) expression in various malignancies have provided invaluable insight into the role of this class of small non-coding RNAs in tumor growth. Evidence of irregular miRNA expression in uterine fibroids has garnered recent interest for diagnostic and therapeutic applications. Since miRNA gene targets modulate several processes implicated in the genesis of uterine fibroids, more focused investigation has the potential to elucidate the functional significance of miRNA in the genesis and pathology of the disease.
    Human Reproduction Update 04/2014; 20(5). DOI:10.1093/humupd/dmu017 · 10.17 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.
    Protein & Cell 06/2014; 5(11). DOI:10.1007/s13238-014-0076-6 · 3.25 Impact Factor


10 Reads
Available from