Sex and diabetes

Diabetes forecast 11/2012; 65(11):48-51.
Source: PubMed
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  • Angiology 04/1974; 25(3):197-227. DOI:10.1177/000331977402500304 · 2.97 Impact Factor
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    ABSTRACT: Ovarian-adrenal interactions on insulin secretion during oestradiol treatment were studied in sham-operated, ovariectomized and adrenalectomized-ovariectomized female rats, the latter thus treated to suppress interference from endogenous hormones. Islets of Langerhans isolated from oestradiol or oestradiol + corticosterone treated and control rats were incubated with various glucose concentrations. Oestradiol treatment enhanced basal and glucose stimulated insulin secretion from sham-operated (+12%) or ovariectomized rats (+24%). This effect disappeared in adrenalectomized-ovariectomized rats but reappeared when adrenalectomized-ovariectomized rats were treated with oestradiol + corticosterone (+37%). A 14-day oestradiol treatment had a trophic effect on total protein content independent of adrenal presence (+14%; +15%; +31%; +23% versus respective control groups). Our data demonstrate that corticosterone is necessary for the stimulating effect of oestradiol on insulin secretion.
    Diabetologia 02/1984; 26(1):76-80. DOI:10.1007/BF00252268 · 6.67 Impact Factor
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    ABSTRACT: The purpose of this work was to study the effects of prolonged mild diabetes on the submandibular salivary glands and testes of male rats over a 22-month period. Diabetes was induced by means of a subtotal pancreatectomy in a group of male rats. Body weight was registered monthly as well as the blood glucose values after fasting the animals. These values were compared with those obtained in sham-operated animals. The weight of pancreatectomized animals was always slightly higher than that of the controls although the differences were not significant, whereas blood glucose values were slightly higher in experimental animals. Testis O2 uptake in pancreatectomized animals was significantly lower than in controls 8 months after the operation. From this time on, the values of experimental animals rose, reaching a maximum value 20 months after the operation. Submandibular glands in pancreatectomized animals showed an O2 uptake that was always higher in experimental animals and reached a maximum value at 20 months.
    Acta Diabetologica 10/1986; 23(4):291-299. DOI:10.1007/BF02582062 · 2.40 Impact Factor
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