Urinary Biomarkers for Phthalates Associated with Asthma in Norwegian Children.

Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway
Environmental Health Perspectives (Impact Factor: 7.26). 11/2012; DOI: 10.1289/ehp.1205256
Source: PubMed

ABSTRACT BACKGROUND: High-molecular weight phthalates in indoor dust have been associated with asthma in children, but few studies have evaluated phthalate biomarkers in association with respiratory outcomes. OBJECTIVES: To explore the association between urinary concentrations of phthalate metabolites and current asthma. METHODS: In a cross-sectional analysis, eleven metabolites of eight phthalates (including four metabolites of di-2-ethylhexyl phthalate) were measured in one first morning void collected between 2001-2004 from 623 10-year old Norwegian children. Logistic regression models controlling for urine specific gravity, sex, parental asthma, and income were used to estimate associations between current asthma and phthalate metabolite concentrations by quartiles or as log10-transformed variables. RESULTS: Current asthma was associated with both mono-carboxyoctyl phthalate (MCOP) and mono-carboxynonyl phthalate (MCNP), although the association was limited to those in the highest quartile of these chemicals. The adjusted odds ratio (aOR) for current asthma was 1.9 (95% confidence interval (CI): 1.0, 3.3) for the highest MCOP quartile compared to the lowest quartile, and 1.3 (95% CI: 0.98, 1.7) for an inter-quartile range increase. The aOR for current asthma was 2.2 (95% CI: 1.2, 4.0) for the highest MCNP quartile and 1.3 (95% CI: 1.0, 1.7) for an inter-quartile range increase. The other phthalate metabolites were not associated with current asthma. CONCLUSIONS: Current asthma was associated with the highest quartiles of MCOP and MCNP, metabolites of two high molecular weight phthalates, di-isononyl phthalate and di-isodecyl phthalate, respectively. Given the short biological half-life of the phthalates and the cross-sectional design, our findings should be interpreted cautiously.

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