Article

Urinary Biomarkers for Phthalates Associated with Asthma in Norwegian Children.

Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway
Environmental Health Perspectives (Impact Factor: 7.26). 11/2012; DOI: 10.1289/ehp.1205256
Source: PubMed

ABSTRACT BACKGROUND: High-molecular weight phthalates in indoor dust have been associated with asthma in children, but few studies have evaluated phthalate biomarkers in association with respiratory outcomes. OBJECTIVES: To explore the association between urinary concentrations of phthalate metabolites and current asthma. METHODS: In a cross-sectional analysis, eleven metabolites of eight phthalates (including four metabolites of di-2-ethylhexyl phthalate) were measured in one first morning void collected between 2001-2004 from 623 10-year old Norwegian children. Logistic regression models controlling for urine specific gravity, sex, parental asthma, and income were used to estimate associations between current asthma and phthalate metabolite concentrations by quartiles or as log10-transformed variables. RESULTS: Current asthma was associated with both mono-carboxyoctyl phthalate (MCOP) and mono-carboxynonyl phthalate (MCNP), although the association was limited to those in the highest quartile of these chemicals. The adjusted odds ratio (aOR) for current asthma was 1.9 (95% confidence interval (CI): 1.0, 3.3) for the highest MCOP quartile compared to the lowest quartile, and 1.3 (95% CI: 0.98, 1.7) for an inter-quartile range increase. The aOR for current asthma was 2.2 (95% CI: 1.2, 4.0) for the highest MCNP quartile and 1.3 (95% CI: 1.0, 1.7) for an inter-quartile range increase. The other phthalate metabolites were not associated with current asthma. CONCLUSIONS: Current asthma was associated with the highest quartiles of MCOP and MCNP, metabolites of two high molecular weight phthalates, di-isononyl phthalate and di-isodecyl phthalate, respectively. Given the short biological half-life of the phthalates and the cross-sectional design, our findings should be interpreted cautiously.

0 Bookmarks
 · 
142 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: There is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies. We sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years. We measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ4DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ3LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente-Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively. The relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ4DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ4DEHP, and MBzP exposure. There were no other exposure-outcome associations. Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
    Journal of Allergy and Clinical Immunology 10/2014; 135(2). DOI:10.1016/j.jaci.2014.09.030 · 11.25 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Assessment of the exposure to chemical substances is an essential element of the quantitative risk assessment. Traditionally, it is performed by measuring their concentrations in the air at the workplace, or in the environmental media. Studies of the behavior of chemicals in the human body provide for another possibility known as “biological monitoring” of the exposure. It takes into account all routes and sources of exposure, making it a reliable tool for risk assessment and risk management for both scientists and policy makers. Establishing a relationship between external exposure to toxic substances and the biological changes that lead to adverse health effects is the basis for the development of appropriate tests for biological control - biomarkers. A quantitative exposure assessment of xenobiotics and their potential impact on living organisms, including humans is performed via the biomarkers. The ideal biomarker of exposure determines the quantity of the chemical associated with the critical sites of impact (critical dose or biologically effective dose). The WHO recommends the principles and methods for determining biomarkers of occupational exposure. In the EU Environment and Health Action Plan 2004- 2010, the European Commission has initiated the development of a harmonized approach to conducting biomonitoring in Europe. Biological monitoring can be used to prioritize actions and measures for policy making aimed at reducing exposure to potentially hazardous environmental stressors and to promote more comprehensive health impact assessments of policy options. Key words: biological monitoring, biomarkers of exposure, chemicals, biological media
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Studies suggest that phthalate exposures may adversely affect child respiratory health.
    Environmental Health Perspectives 09/2014; DOI:10.1289/ehp.1307670 · 7.03 Impact Factor

Full-text (3 Sources)

Download
1 Download
Available from
Mar 20, 2015