Pharmacognostic Evaluation and Anthelmintic Activity of Leaf and Stem Extract of Carica papaya

Journal of Pharmacy Research 11/2012; 5(9):4763-4766.


This research was conducted to evaluate the possible antihelmintic activity of leaf and stem of Carica papaya as a potent remedy in both human and veterinary practices using Indian adult earth worm (Pheretima posthuma) as a test worm. Various concentration (5%, 2.5%, 1%) were invitro tested using different extracts like ( hydroalcoholic, chloroform) and the results were involved in terms of time for paralysis (P) and time for death (D). It showed shortest time for paralysis in 5% concentration while the time for paralysis and death will increase in 2.5% and 1% respectively as compared to standard drug Albendazole. The present study indicated that the leaf and stem of Carica papaya has a significant anthelmintic activity and can be a potent drug due to, cost benefit and easy availability.

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Available from: Saumendu Deb Roy, Oct 05, 2015
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    ABSTRACT: The aim of present study is to evaluate Anthelmintic potential of latex of Carica papaya using Pheretima posthuma as test worms. Various concentrations (100%, 50%, and 20%) of Carica papaya latex were tested in the assay, which involved determination of time of paralysis (P) and time of death (D) of the worms. It show shortest time of paralysis (P=24.5 min) and death (D=56min) in 100% concentration, while the time of paralysis and death will increase in 50% concentration (P=28min&D=64min) and in 20% concentration (P=34min&D=74min) respectively as compare to Piperazine citrate (10mg/ml) used as standard reference (P= 24 min& D= 54) and distilled water as control. The results of present study indicated that the latex of Carica papaya showed significantly demonstrated paralysis, and also caused death of worms especially at higher concentration as compared to standard reference Piperazine citrate and control.From the result it is conclude that the latex of Carica papaya showed significant Anthelmintic activity.
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    ABSTRACT: Extracts of plants, such as papaya, pineapple and fig, are known to be effective at killing intestinal nematodes that inhabit anterior sites in the small intestine, such as Heligmosomoides polygyrus. In this paper, we demonstrate that similar in vitro efficacy also occurs against a rodent nematode of the large intestine, Trichuris muris, and confirm that the cysteine proteinases present in the plant extracts are the active principles. The mechanism of action of these enzymes involved an attack on the structural proteins of the nematode cuticle, which was similar to that observed with H. polygyrus. However, not all plant cysteine proteinases were equally efficacious because actinidain, from the juice of kiwi fruit, had no detrimental effect on either the motility of the worms or the nematode cuticle. Papaya latex was also shown to significantly reduce both worm burden and egg output of mice infected with adult T. muris, demonstrating that enzyme activity survived passage to the caecum and was not completely inactivated by the acidity of the host's stomach or destroyed by the gastric or pancreatic proteinases. Thus, the cysteine proteinases from plants may be a much-needed alternative to currently available anthelmintic drugs due to their efficacy and novel mode of action against different gastrointestinal nematode species.
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    ABSTRACT: An experiment was carried out to investigate the anthelmintic activity of papaya latex (Carica papaya) against natural infection of Ascaris suum in pigs. Sixteen naturally infected pigs were, on the basis of faecal egg counts and body weight, allocated into four groups, each of four pigs. Three groups (groups B, C, and D) were given papaya latex per os at dose levels of 2, 4, and 8 g of papaya latex per kg body weight, respectively. The fourth group (group A) served as a non-treated control. Results of post mortem counts on day 7 post treatment revealed worm count reductions of 39.5, 80.1 and 100% in groups B, C, and D, respectively. Some of the pigs receiving the highest dose of the latex showed mild diarrhoea on the day following treatment. Otherwise, no clinical or pathological changes were observed in the treated animals. The possible future use of this traditional herbal medicine for livestock and humans is discussed.
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