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Pharmacognostic Evaluation and Anthelmintic Activity of Leaf and Stem Extract of Carica papaya

Journal of Pharmacy Research 11/2012; 5(9):4763-4766.

ABSTRACT This research was conducted to evaluate the possible antihelmintic activity of leaf and stem of Carica papaya as a potent remedy in both human and veterinary practices using Indian adult earth worm (Pheretima posthuma) as a test worm. Various concentration (5%, 2.5%, 1%) were invitro tested using different extracts like ( hydroalcoholic, chloroform) and the results were involved in terms of time for paralysis (P) and time for death (D). It showed shortest time for paralysis in 5% concentration while the time for paralysis and death will increase in 2.5% and 1% respectively as compared to standard drug Albendazole. The present study indicated that the leaf and stem of Carica papaya has a significant anthelmintic activity and can be a potent drug due to, cost benefit and easy availability.

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    ABSTRACT: An experiment was carried out to investigate the anthelmintic activity of papaya latex (Carica papaya) against natural infection of Ascaris suum in pigs. Sixteen naturally infected pigs were, on the basis of faecal egg counts and body weight, allocated into four groups, each of four pigs. Three groups (groups B, C, and D) were given papaya latex per os at dose levels of 2, 4, and 8 g of papaya latex per kg body weight, respectively. The fourth group (group A) served as a non-treated control. Results of post mortem counts on day 7 post treatment revealed worm count reductions of 39.5, 80.1 and 100% in groups B, C, and D, respectively. Some of the pigs receiving the highest dose of the latex showed mild diarrhoea on the day following treatment. Otherwise, no clinical or pathological changes were observed in the treated animals. The possible future use of this traditional herbal medicine for livestock and humans is discussed.
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May 21, 2014