Article

Gout in women: differences in risk factors in young and older women.

Department of Rheumatology, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland 1640, New Zealand. .
The New Zealand medical journal 01/2012; 125(1363):39-45.
Source: PubMed

ABSTRACT To describe the clinical characteristics of female patients with gout, assess risk factors in this group and to identify any differences between pre- and postmenopausal women with this diagnosis.
We retrospectively reviewed the case records of all women who were seen with gout in a secondary care setting (inpatient and outpatient) at Counties Manukau District Health Board between July 2007 and July 2008. Demographic data, risk factors for gout and information on urate-lowering therapy was collected. A cut-off of less than and equal to 50 years was used to estimate pre-menopausal status.
122/509 (24%) of patients seen with gout were female. Fourteen female patients were less than or equal to 50 years of age; all of these patients were either Maori (43%) or of Pacific Island ethnicity (57%). Comorbidities in those =50 years old were renal impairment (78.6%), hypertension (64.3%), congestive heart failure (43%) and diabetes mellitus (42.9%). Comorbidities in women >50 years old were similar: hypertension (77%), renal impairment (70%), dyslipidemia (53%) and diabetes mellitus (50%). Ischemic heart disease was more common in older women (43% vs 7%), P<0.01. Mean body mass index (BMI) was significantly higher in the younger women (43.5 vs 33.1), P<0.01. Half of all the female patients were on diuretics, and medication used to lower uric acid level was prescribed in 35.7% of women less than and equal to 50 years of age, and 42.59% of women >50 years of age.
Women who develop gout are more likely to be over the age of 50, have other comorbidities and be on diuretics. In comparison, younger women who develop gout have similar risk factors but tended to have a higher body mass index and are more likely to be of Maori or Pacific Island ethnicity.

0 Bookmarks
 · 
67 Views
  • Bulletin on the rheumatic diseases 02/1982; 32(6):59-68.
  • [Show abstract] [Hide abstract]
    ABSTRACT: First identified by the Egyptians in 2640 BC, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. The term is derived from the Latin word gutta (or 'drop'), and referred to the prevailing medieval belief that an excess of one of the four 'humors'--which in equilibrium were thought to maintain health--would, under certain circumstances, 'drop' or flow into a joint, causing pain and inflammation. Throughout history, gout has been associated with rich foods and excessive alcohol consumption. Because it is clearly associated with a lifestyle that, at least in the past, could only be afforded by the affluent, gout has been referred to as the 'disease of kings'. Although there is evidence that colchicine, an alkaloid derived from the autumn crocus (Colchicum autumnale), was used as a powerful purgative in ancient Greece more than 2000 years ago, its first use as a selective and specific treatment for gout is attributed to the Byzantine Christian physician Alexander of Tralles in the sixth century AD. Uricosuric agents were first used at the end of the 19th century. In the modern era, nonsteroidal anti-inflammatory drugs are usually the drugs of choice for treating acute gout. Perhaps the most important historical advance in the treatment of hyperuricemia was the development of xanthine oxidase inhibitors, which are effective in reducing plasma and urinary urate levels and have been shown to reverse the development of tophaceous deposits.
    Arthritis research & therapy 02/2006; 8 Suppl 1(Suppl 1):S1. DOI:10.1186/ar1906 · 4.12 Impact Factor
    This article is viewable in ResearchGate's enriched format
  • Nephrology Dialysis Transplantation 03/2005; 20(2):431-3. DOI:10.1093/ndt/gfh629 · 3.49 Impact Factor

Full-text

Download
12 Downloads
Available from
Sep 15, 2014