Article

Kidney stone formation is positively associated with conventional risk factors for coronary heart disease in Japanese men

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: .
The Journal of urology (Impact Factor: 3.75). 11/2012; 189(4). DOI: 10.1016/j.juro.2012.11.045
Source: PubMed

ABSTRACT PURPOSE: To investigate the association between kidney stones and risk factors of CHD in Japanese men. MATERIAL AND METHODS: This cross-sectional study consisted of 13,418 Japanese men aged 30-69 years, who voluntarily received medical examinations, between April 1995 and March 2001. The participants were divided into three groups (controls, past, and current kidney stone formers) based on US results and medical histories. Conventional risk factors of CHD (overweight/obesity, hypertension, DM, gout/hyperuricemia, dyslipidemia and CKD) were evaluated. Associations between risk factors of CHD and kidney stone formation were investigated. RESULTS: Of the 13,418 participants, 404 (3.0%, current kidney stone formers) had kidney stones by US and 1,231 (9.2%, past kidney stone formers) had a history of kidney stones but did not have kidney stones at the medical examination. BMI, systolic and diastolic BP, and serum UA were significantly higher in both past and current kidney stone formers than in controls. Logistic regression analysis indicated that the multivariate-adjusted ORs (95% CI) for overweight/obesity, hypertension, gout/hyperuricemia, and CKD, significantly increased in the order corresponding to controls, past and current kidney stone formers. CONCLUSION: Kidney stone formers, even past stone formers, are likely to have accumulated risk factors of CHD and could be preferentially targeted for CHD prevention.

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