Article

A window into the invisible wound of war: Functional neuroimaging of REM sleep in returning combat veterans with PTSD

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: .
Psychiatry research 11/2012; 211(2). DOI: 10.1016/j.pscychresns.2012.05.007
Source: PubMed

ABSTRACT Relative regional cerebral metabolic rate of glucose in rapid eye movement (REM) sleep and wakefulness was explored in combat veterans with and without PTSD, using positron emission tomography. Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD.

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    • "Studies have demonstrated that neural substrate (i.e., amygdala, hippocampus, medial prefrontal cortex) activity governing arousal and threat response is in fact exaggerated in anxiety disorders, such as PTSD (Rauch et al., 2003, 2000; Stein and Nesse, 2011). As such, the present findings revealing decreased rCMRglc in these structures suggest that REM sleep, as well as wakefulness, may be compromised following exposure to mTBI, independent of the effects of PTSD symptomology (Germain et al., 2013). Future research should continue to focus on the neurobiological sequelae of blast exposure, relative to other types of mTBI and after adjusting for PTSD, during wakefulness, REM sleep, and NREM sleep. "
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