Article

Low Bone Mineral Density, Regardless of HIV Status, in Men Who Have Sex With Men

Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam.
The Journal of Infectious Diseases (Impact Factor: 5.85). 11/2012; 207(3). DOI: 10.1093/infdis/jis687
Source: PubMed

ABSTRACT A high prevalence of low bone mineral density (BMD) has been reported in primary and chronic HIV-infected men. To gain further insight into the contribution of HIV-infection, we compared the BMD of 41 primary and 106 chronic HIV-infected men who have sex with men (MSM) with the BMD of a control group of 30 HIV-negative MSM. Low BMD, defined as a Z-score ≤ -2.0 SD at the lumbar spine or hip, was highly prevalent in all three groups. In the multivariate analyses, HIV-infection was not associated with BMD, suggesting that low BMD previously reported in HIV-infected MSM may pre-date HIV-acquisition.

0 Bookmarks
 · 
92 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Concern has been raised that HIV infection, its treatment, or both adversely affect skeletal health. Cross-sectional studies show that bone mineral density (BMD) is 3-5% lower in patients infected with HIV than in uninfected controls, but patients with HIV infection are, on average, 5 kg lighter than uninfected people. After this weight difference is accounted for, BMD differences are smaller and not clinically relevant. Longitudinal studies show short-term BMD loss of 2-4% over 1-2 years when antiretroviral therapy is started, followed by longer periods of BMD increase or stability. Losses are greatest with treatment regimens that contain tenofovir. Patients infected with HIV have slightly higher fracture rates than controls, but the increased risk of fracture is substantially attenuated by adjustment for traditional risk factors for fracture. These reassuring findings suggest that management of skeletal health in HIV should follow guidelines for the general population. In general, effective antiretroviral treatment and avoidance of undernutrition are the two most important factors for maintenance of skeletal health in patients infected with HIV.
    02/2014; 3(1). DOI:10.1016/S2213-8587(13)70181-5
  • [Show abstract] [Hide abstract]
    ABSTRACT: Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractures in those living with HIV and identifies remaining gaps in our knowledge of this complex but increasingly important aspect of ageing research in HIV.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Low bone mineral density (BMD) is common in HIV-positive patients, although the role played by HIV infection versus sociodemographic and metabolic factors remains unclear.
    AIDS (London, England) 09/2014; 28(14):2051-60. DOI:10.1097/QAD.0000000000000353 · 6.56 Impact Factor