Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate beta-diketiminate ligand

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. .
Dalton Transactions (Impact Factor: 4.1). 11/2012; 42(9). DOI: 10.1039/c2dt32462h
Source: PubMed

ABSTRACT A platinum(ii) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDI(QQ)H, is reported. The complex, [Pt(BDI(QQ))]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and (1)H NMR spectroscopy indicate that [Pt(BDI(QQ))]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.

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