Article

Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children.

1Department of Sports, Faculty of teacher Education and Sports, SognogFjordane University College, Box 133- N, 6851 Sogndal, Norway 2Department of Sports Medicine, Norwegian School of Sport Sciences, PO Box 4014 UllevålStadion, 0806 Oslo, Norway.
Medicine and science in sports and exercise (Impact Factor: 4.48). 11/2012; DOI: 10.1249/MSS.0b013e318279707a
Source: PubMed

ABSTRACT PURPOSE: The purpose of this study was to describe levels of inflammation markers in Norwegian children and to examine the associations of adiposity, aerobic fitness and muscle fitness with markers of inflammation. METHODS: In 2005-2006, 1467 9-year-olds wererandomly selected from all regions in Norway. The participation rate was 89%. The inflammatory markers evaluated included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis factor- α (TNF-α), hepatocyte growth factor, resistin and interleukin-6. We assessed muscular strength by measuring explosive, isometric and endurance strength. Aerobic fitness was measured directly during a maximal cycle ergometer test. Adiposity was expressed as waist circumference (WC). RESULTS: The girls had significantly higher levels of CRP, leptin, adiponectin and resistin and lower levels of TNF-α compared to the boys. We observed a graded association of CRP and leptin levels across quintiles of WC, aerobic fitness and muscle fitness (P ≤0.001 for all participants). The regression analyses revealed that WC, aerobic fitness and muscle fitness were independently associated with the CRP (WC β= 0.158, P < 0.001; aerobic fitness β= -0.190, P < 0.001; muscle fitness β= -0.158, P < 0.002) after adjustments for gender, age, Tanner pubertal stage and the other independent variables. The same pattern was observed for leptin levels (WC β= 0.406, P < 0.001; aerobic fitness β= -0.298, P < 0.001; muscle fitness β= -0.064, P < 0.036). CONCLUSIONS: These data represent a reference material with respect to inflammatory markers. Our results show that adiposity, aerobic and muscle fitness were independently associated with the CRP and leptin levels.

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