A Conceptual Framework of Health Related Quality of Life Impact in Acute Gastroenteritis.

*Child Health Evaluative Sciences, SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada †Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario, Canada ‡Division of Paediatric Urology, Hospital for Sick Children, Ontario, Canada §Faculty of Health Sciences, McMaster University, Ontario, Canada ||Department of Pediatrics, McMaster University, Ontario, Canada.
Journal of pediatric gastroenterology and nutrition (Impact Factor: 2.87). 11/2012; DOI: 10.1097/MPG.0b013e3182736f49
Source: PubMed

ABSTRACT BACKGROUND AND OBJECTIVES:: To date, most trials in pediatric acute gastroenteritis have evaluated short-term clinical disease activity (e.g. duration of diarrhea or vomiting, level of dehydration), laboratory outcomes (e.g. rotavirus, norovirus) or a composite of these outcomes. Measuring health-related quality of life may also be important in evaluating the impact of interventions for acute gastroenteritis in children. The objectives were to conduct individual interviews and, when possible, focus group discussions, with parents of children with acute gastroenteritis; to determine how parent and child quality of life is negatively impacted by acute gastroenteritis; and, from the perspective of parents and children, to develop a conceptual framework for quality of life instrument specific to pediatric acute gastroenteritis. METHODS:: We conducted interviews and focus groups with parents of children (3 months to 5 years of age) given a diagnosis of gastroenteritis in a hospital emergency department. Interviews and focus groups were conducted to determine the impact of gastroenteritis on quality of life in parents and children (as perceived by the parents). RESULTS:: Interviews and focus groups involving 25 parents suggested a conceptual framework that, for children, includes two domains (physical and emotional function) and fourteen sub-domains. For parents, our framework includes three domains (physical, emotional and social function) with physical function including four sub-domains, emotional function including seven sub-domains, and social function including two sub-domains. The framework has been used to develop a preliminary quality of life questionniare for parents and children. CONCLUSIONS:: Acute gastroenteritis has an important adverse impact on health-related quality in both children and parents involving physical symptoms and restrictions in physical function and disturbed emotional function. Upon further research on the psychometric properties of the proposed questionnaires, future trials of effectiveness should consider measuring patient important outcomes such as health-related quality of life.

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