Biobanking past, present and future: responsibilities and benefits

University of California, San Francisco, San Francisco, California, United States
AIDS (London, England) (Impact Factor: 6.56). 11/2012; 27(3). DOI: 10.1097/QAD.0b013e32835c1244
Source: PubMed

ABSTRACT This review explores the field of biobanking as it has evolved from a simple collection of frozen specimens to the virtual biobank. Biorepository and biospecimen science has evolved in response to the changing landscape of external regulatory pressures, the advances made in the biological sciences, and the advent of the computer chip. Biospecimen banking is a growing enterprise crucial to health science research and other biological sciences. In this review we discuss the history of biobanking, highlight current and emerging issues, discuss demands and responses, and describe an example of a biobank, the UCSF AIDS Specimen Bank that has functioned for 30 years.

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    ABSTRACT: Effective tracking of biospecimens within a biobank requires that each biospecimen has a unique identifier (ID). This ID can be found on the sample container as well as in the biospecimen management system. In the latter, the biospecimen ID is the key to annotation data such as location, quality, and sample processing. Guidelines such as the Best Practices from the International Society of Biological and Environmental Repositories only state that a unique identifier should be issued for each sample. However, to our knowledge, all guidelines lack a specific description of how to actually generate such an ID and how this can be supported by an IT system. Here, we provide a guide for biobankers on how to generate a biospecimen ID for your biobank. We also provide an example of how to apply this guide using a longitudinal multi-center research project (and its biobank). Starting with a description of the biobank's purpose and workflows through to collecting requirements from stakeholders and relevant documents (i.e., guidelines or data protection concepts), and existing IT-systems, we describe in detail how a concept to develop an ID system can be developed from this information. The concept contains two parts: one is the generation of the biospecimen ID according to the requirements of stakeholders, existing documentation such as guidelines or data protection concepts, and existing IT-infrastructures, and the second is the implementation of the biospecimen IDs and related functionalities covering the handling of individual biospecimens within an existing biospecimen management system. From describing the concept, the article moves on to how the new concept supports both existing or planned biobank workflows. Finally, the implementation and validation step is outlined to the reader and practical hints are provided for each step.
    Biopreservation and Biobanking 06/2014; 12(3):199-205. DOI:10.1089/bio.2013.0085 · 1.58 Impact Factor
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    PLoS Neglected Tropical Diseases 08/2014; 8(8):e3023. DOI:10.1371/journal.pntd.0003023 · 4.49 Impact Factor
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    ABSTRACT: This paper presents a placement method of fuzzy logic based unified power flow controller (UPFC) in power system network by analyzing dynamic voltage stability. Voltage stability indices namely LQP and voltage collapse point indicators (VCPI) indices are used to determine the weakest line for UPFC by dynamic load variation. The controllers of the shunt and series converters of the UPFC are developed using fuzzy logic (FL) and proportional integral (PI) controllers respectively to enhance the dynamic voltage stability of the power system network.The simulation has been conducted in power system computer-aided design (PSCAD) environment where IEEE-5 and IEEE-14 bus system have been chosen as test bench systems. The results obtained through simulations have ensured the effectiveness of the proposed placement method since fuzzy based UPFC’s placement in the obtained locations resulted in significant improvement in voltage stability.
    Power Electronics and Applications (EPE'14-ECCE Europe), Lappeenranta, Finland; 08/2014


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Jan 7, 2015