Dietary intakes of carbohydrates in relation to prostate cancer risk: A prospective study in the Malmö Diet and Cancer cohort
Research Group in Nutritional Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden, and the Department of Urology, Skåne University Hospital, Malmö, Sweden. American Journal of Clinical Nutrition
(Impact Factor: 6.77).
11/2012; 96(6). DOI: 10.3945/ajcn.112.039438
BACKGROUND: Dietary carbohydrates have been implicated in relation to prostate cancer. OBJECTIVE: Our objective was to examine the associations between dietary intakes of carbohydrates, fiber, and their food sources and risk of prostate cancer, overall and by case severity, in the Malmö Diet and Cancer cohort. DESIGN: The analysis included 8128 men aged 45-73 y without a history of cancer, cardiovascular disease, or diabetes and who were classified as adequate energy reporters. After a median follow-up time of 15 y, prostate cancer was diagnosed in 817 men. We used Cox proportional hazards regression to model associations between energy-adjusted nutrient and food intakes with risk of incident prostate cancer, with competing risk of death from non-prostate cancer causes taken into account. RESULTS: After adjustment for age and other known or potential risk factors, we observed no associations between total carbohydrates or dietary fiber and prostate cancer. We observed positive associations between the intake of low-fiber cereals with overall and low-risk prostate cancer and between intakes of cake and biscuits and rice and pasta with low-risk prostate cancer (all P-trend < 0.05). A high intake compared with zero consumption of sugar-sweetened beverages was associated with increased risk of symptomatic prostate cancer (HR: 1.38; 95% CI: 1.04, 1.84). CONCLUSIONS: Results from this large study with high-validity dietary data suggest that a high intake of refined carbohydrates may be associated with increased risk of prostate cancer. However we observed no significant associations with high-risk prostate cancer, and not all foods that are typically high in refined carbohydrates were associated with prostate cancer.
Available from: William CS Cho
- "" The literature contains ample consensus that eating such foods favors the onset of obesity and diabetes, both factors in cancer development. For example, a high intake of refined carbohydrates has been associated with cancer in general  and more specifically with prostate cancer . Fructose intake, which is also associated with obesity, has been shown to be used preferentially by pancreatic cancer cells to grow  and cancer of the small intestine . "
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ABSTRACT: The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting.
Evidence-based Complementary and Alternative Medicine 10/2013; 2013:917647. DOI:10.1155/2013/917647 · 1.88 Impact Factor
MMW Fortschritte der Medizin 05/2012; 154 Suppl 1:34-6.
American Journal of Clinical Nutrition 11/2012; 96(6). DOI:10.3945/ajcn.112.051417 · 6.77 Impact Factor
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