Article

Catalytic asymmetric syntheses of tyrosine surrogates.

Neuroscience Discovery Chemistry, Research & Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
The Journal of Organic Chemistry (impact factor: 4.45). 11/2008; 73(21):8502-10. DOI:10.1021/jo801577t pp.8502-10
Source: PubMed

ABSTRACT Amino acid esters 5-11 as tyrosine mimics have been synthesized in excellent enantioselectivity (up to 99.6% ee) and in good overall chemical yields. The key step in the sequence was the Burk's [Rh(COD)(2R,5R)-Et-DuPhos]BF4-catalyzed asymmetric hydrogenation of enamides with a variety of reactive functional groups.

0 0
 · 
0 Bookmarks
 · 
30 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

Amino acid esters 5-11
 
key step
 
reactive functional groups