Histopathologic characteristics of the primary tumor in breast cancer patients with isolated tumor cells of the sentinel node

Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
Surgery (Impact Factor: 3.38). 10/2008; 144(4):518-24; discussion 524. DOI: 10.1016/j.surg.2008.06.006
Source: PubMed


Clinicians often rely on primary tumor characteristics to decide on adjuvant treatment for patients with breast cancer with isolated tumor cells (ITC) in the sentinel lymph node. The purpose of this study was to determine if there is a significant difference in primary tumor characteristics between ITC and other nodal groups.
Patients undergoing sentinel lymphadenectomy were divided into 3 groups: N0, no metastases; ITC, metastasis less than 0.2 mm; and micro- or macrometastases (MM), metastasis greater than 0.2 mm. The chi-square test and analysis of variance were used.
A total of 552 patients underwent sentinel lymphadenectomy; 197 (36%) had tumor-positive sentinel lymph nodes. Of these, 35 (18%) were classified as ITC and 162 (82%) as MM. When primary tumor characteristics were compared, the ITC group had significantly more lymphovascular invasion and higher proliferative rate than the N0 group (P < .05) and significantly less lymphovascular invasion, lower proliferative rate, and smaller tumor size (P < .05) than the MM group. There were no significant differences in the age, hormone receptor status, histologic type, or tumor grade among the patient groups.
Proliferation and lymphovascular invasion of the primary tumor are significantly different between the ITC, N0, and MM groups suggesting that ITC tumors may have different biology than the N0 or MM tumors.

5 Reads
  • Source
    Cancer 04/2009; 115(7):1361-2. DOI:10.1002/cncr.24194 · 4.89 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: Sentinel lymph node (SLN) biopsy has replaced unnecessary axillary dissection in breast cancer surgery except when the nodes are positive for macrometastasis. But guidelines for isolated tumor cells (ITCs) found in SLNs has not yet been established and further study is ongoing. The goal of this study was to consider the implication of the isolated tumor cells found in the SLNs of Korean breast cancer patients. Methods: Between September 2003 and March 2008, 985 primary breast cancer patients Underwent SLN biopsy. On reviewing the medical records, 81. patients were found to have ITCs in SLNs without macrometastasis or micrometastasis. ITCs were detected by serial sectioning and immunohistochemistry. Results: The mean number of detected SLNs was 3.5 +/- 1.7. Thirty three patients had multifocally distributed ITCs and 9 had ITCs in multiple SLNs whose N stage was N0 (i+). Completion axillary dissection has been performed in 9 patients and 3 of them (33.3%) finally were found to be N1 or N1mi. Conclusion: The characteristics of ITCs are not clear yet and their prognostic value is still under investigation. Until the significance of ITCs found in SLNs become definite, axillary dissection should be more aggressively considered. (J Korean Surg Soc 2009;77:378-384)
    Journal of the Korean Surgical Society 12/2009; 77(6). DOI:10.4174/jkss.2009.77.6.378 · 0.73 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasion and sentinel lymph node (SLN) metastasis. Of 255 patients with DCIS, 199 had definitive surgery and 52 (26%) had invasive ductal carcinoma (IDC) on final excision. Extent of abnormal microcalcification on mammography, and presence of a radiologic/palpable mass and solid type of DCIS were significantly associated with invasion on final excision. Sentinel lymph node biopsy was performed in 131 (65.8%) patients of whom 18 (13.4%) had metastasis. Size of IDC and extent of DCIS on final pathology were significantly associated with positive SLN. Micrometastasis and isolated tumor cells comprised majority (71.4%) of the metastases in DCIS. SLN biopsy should be considered in those with high risk DCIS.
    The Breast Journal 05/2011; 17(3):223-9. DOI:10.1111/j.1524-4741.2011.01069.x · 1.41 Impact Factor
Show more