Tobacco and tuberculosis.
ABSTRACT Smoking is not only the most important source of avoidable disability and death, but a risk factor for TB infection, disease and death. Even passive smoking exposure may increase the risk of infection and disease in adults and children exposed to TB. Considering the increase in tobacco consumption in developing countries, where the prevalence of TB is the highest, smoking may be responsible for a large part of the burden of disease. Therefore, medical advice and counselling in smoking cessation is an important activity for all care providers engaged in management of TB.
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Article: [Smoking and active tuberculosis].[Show abstract] [Hide abstract]
ABSTRACT: The link between tuberculosis and HIV infection has long been established but the link between tuberculosis and smoking is not well understood. However, many patients with tuberculosis are smokers and an increasing proportion of them live in developing countries where there is a high incidence of the disease. Smoking increases the risk of tuberculosis and of subsequent death from the disease. Henceforth, smoking cessation will become a way of controlling the tuberculosis epidemic in developing nations. This evidence must be used to mobilize an international effort to deal with these two major public health issues.Revue des Maladies Respiratoires 10/2012; 29(8):978-93. · 0.50 Impact Factor
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ABSTRACT: There is sufficient evidence to conclude that tobacco smoking is strongly linked to tuberculosis (TB) and a large proportion of TB patients may be active smokers. In addition, a previous analysis has suggested that a considerable proportion of the global burden of TB may be attributable to smoking. However, there is paucity of information on the prevalence of tobacco smoking among TB patients in Malaysia. Moreover, the tobacco-related knowledge, attitudes, and behaviors of TB patients who are smokers have not been previously explored. This study aimed to document the prevalence of smoking among newly diagnosed TB patients and to learn about the tobacco use knowledge and attitudes of those who are smokers among this population. Data were generated on prevalence rates of smoking among newly diagnosed TB patients in the State of Penang from January 2008 to December 2008. The data were obtained based on a review of routinely collated data from the quarterly report on TB case registration. The study setting comprised of five healthcare facilities (TB clinics) located within Penang and Wilayah Persekutuan, Kuala Lumpur health districts in Malaysia, which were involved in a larger project, known as SCIDOTS Project. A 58-item questionnaire was used to assess the tobacco use knowledge, attitudes and behaviors of those TB patients who were smokers. Smoking status was determinant in 817 of 943 new cases of TB from January to December 2008. Of this, it was estimated that the prevalence rates of current- and ex-smoking among the TB patients were 40.27% (329/817) and 13.95% (114/817), respectively. The prevalence of ever-smoking among patients with TB was estimated to be 54,220 per 100,000 population. Of 120 eligible participants for the SCIDOTS Project, 88 responded to the survey (73.3% response rate) and 80 surveys were analyzed (66.7% usable rate). The mean (+/- SD) total score of tobacco use knowledge items was 4.23 +/- 2.66 (maximum possible score=11). More than half of the participants (51.3%) were moderately dependent to nicotine. A moderately large proportion of the respondents (41.2%) reported that they have ever attempted to quit smoking, while more than half (56.3%) have not. Less than half (47.5%) of the study participants had knowledge about the body system on which cigarette smoking has the greatest negative effect. The majority wrongly believed that smokeless tobacco can increase athletic performance (60%) and that it is a safe and harmless product (46.2%). An overwhelming proportion (>80%) of the patients believed that: smoking is a waste of money, tobacco use is very dangerous to health, and that smokers are more likely to die from heart disease when compared with non-smokers. The use of smokeless tobacco was moderately prevalent among the participants with 28.8% reporting ever snuffed, but the use of cigar and pipe was uncommon. Smoking prevalence rate is high among patients with TB in Malaysia. These patients generally had deficiencies in knowledge of tobacco use and its health dangers, but had positive attitudes against tobacco use. Efforts should be geared towards reducing tobacco use among this population due to its negative impact on TB treatment outcomes.Tobacco Induced Diseases 01/2010; 8(1):3.
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ABSTRACT: It has been reported that tobacco smoking slows the sterilisation of sputum culture in pulmonary tuberculosis, but the factors that could delay culture conversion in patients who smoke are not known. Our aim is to identify the factors influencing sputum culture conversion in smokers with pulmonary tuberculosis. Ninety-nine patients with a smoking history and diagnosed with pulmonary tuberculosis were analysed retrospectively. The relationship between sputum culture status at the second month and the following variables: age, gender, pack-years index, comorbid diseases, number acid-fast bacilli (AFB) in sputum smear examination, radiological findings (cavitary, extensive or limited disease), drug susceptibility pattern and initial treatment, was analysed. The Student t-test, chi-square test and logistic regression model with forward stepwise conditional methods were used for statistical analysis. A p value of <0.05 was considered to be statistically significant. Twenty six patients (26.2%): 18 males (22.2%) and 8 females (44%) were sputum culture positive at the end of the second month of treatment. In univariate analysis, culture conversion time was significantly associated with female gender and extensive disease, but in a logistic regression analysis was only correlated with female gender (OR=5.63 95% CI 1.21-20.64-p=0.02). In current smokers with pulmonary tuberculosis, the 'time to culture' conversion relates only to the female gender.Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 09/2009; 71(3):127-31.
Monaldi Arch Chest Dis
2008; 69: 2, 83-85
Tobacco and tuberculosis
Human beings are not all equally sensitive to
infection with M. tuberculosis if exposed to a
source of contamination. Among persons exposed
to the contact with an index case with transmissi-
ble tuberculosis, some will develop a latent infec-
tion. Of those with a latent tuberculosis infection,
some will develop a clinical tuberculosis, and
among those suffering from tuberculosis some will
die. Several individual factors modulate these
risks. Many of them, like HIV infection, steroid
treatment or diabetes, are related to the immune
defence mechanisms. Smoking, as one of the most
potent irritants to the airways, also influences the
local immune mechanisms of defence against in-
fection and has long been suspected of influencing
the development and outcome of tuberculosis, but
the evidence were anecdotal . Other factors, fre-
quently associated with tuberculosis and with
smoking, like abuse of alcohol, social deprivation,
homelessness and unemployment were suspected
to confound the relation [2, 3]. Recently, two sys-
tematic reviews of the existing literature have ad-
dressed in details the possible influence of smok-
ing on several aspects of tuberculosis and have
come to remarkably similar conclusions [4, 5]. Si-
multaneously, The International Union against TB
and Lung Disease and the WHO have prepared
documents addressing the relations between tobac-
co and tuberculosis, and a plan for further action
The mechanisms by which tobacco smoke can
influence the mucosal defences responsible for the
control of mycobacterial infection include the in-
crease of the production of bronchial secretions,
the decrease in mucociliary clearance, and the im-
pairment of macrophage function. This leads to a
decrease of bacterial adherence at the surface of
macrophages, a decrease of their phagocytic abili-
ty, a decrease of the release of proinflammatory
cytokines with impaired intracellular killing ca-
pacity and a reduced production of TNF-a and ni-
tric oxide (summary in ).
The influence of tobacco smoke on tuberculo-
sis can be assessed for different types of risk:
a) risk of infection if exposed to tuberculosis
(children exposed to passive smoking and
b) risk of disease if infected, (adults and chil-
c) risk of death from tuberculosis.
Risk of infection (if exposed)
Smokers have an increase in the risk of infec-
tion (usually assessed by the size of the tuberculin
reaction) if exposed to tuberculosis. This increase
has been observed in adult smokers, as well as in
non-smoking adults and children passively ex-
posed to tobacco smoke. The risk for children pas-
sively exposed to tobacco smoke and tuberculosis
was assessed in several studies in US , India
, South Africa  and Spain . The rela-
tive risk was proportional to the intensity and du-
ration of exposure and is evaluated between 1.7
and 3.2. The increased risk of infection for active
smokers was demonstrated in UK among elderly
nursing home residents , in adults in South
Africa , and Vietnam  and in incarcerated
adults in Pakistan . The risk is also proportion-
al to the intensity and duration of smoking. The
OR lies between 1.72 and 3.2 .
Risk of disease (if infected)
Once infected, only a minority of patients will
develop tuberculosis, estimates being between
10% for adults and 50% for infants under the age
of 1 year . Individual factors influence this
rate, the most important being immune deficiency
due to HIV, immunosuppressive therapy or dia-
Keywords: Tobacco smoke, Tuberculosis, Infection, Passive smoking, Developing countries.
Department of ambulatory care and community medicine, University of Lausanne, Switzerland.
Correspondence: Jean-Pierre Zellweger, MD, Department of ambulatory care and community medicine, University of Lausanne,
Switzerland; e-mail: firstname.lastname@example.org
ABSTRACT: Tobacco and tuberculosis. J.P. Zellweger.
Smoking is not only the most important source of avoid-
able disability and death, but a risk factor for TB infection,
disease and death. Even passive smoking exposure may in-
crease the risk of infection and disease in adults and children
exposed to TB. Considering the increase in tobacco con-
sumption in developing countries, where the prevalence of
TB is the highest, smoking may be responsible for a large
part of the burden of disease. Therefore, medical advice and
counselling in smoking cessation is an important activity for
all care providers engaged in management of TB.
Monaldi Arch Chest Dis 2008; 69: 2, 83-85.
betes. The increase in risk for smokers compared
to non smokers is evaluated up to 4.6 for the de-
velopment of disease. Furthermore, passive smok-
ing exposure also increases the risk of developing
tuberculosis if infected, particularly among chil-
dren, where the relative risk is between 5 and 9.3
One of the reviews also addressed the relation
between exposure to indoor air pollution (mainly
wood smoke from cooking, a general problem in
many developing countries) and demonstrated that
this was also associated with a higher risk of TB
Death from tuberculosis
Once tuberculosis has developed, most pa-
tients will be cured by an adequate treatment but in
some settings the death rate may still be elevated.
This is particularly the case among elderly patients
with diverse comorbidities, patients with lung de-
struction and chronic obstructive pulmonary dis-
eases. The OR for death from tuberculosis associ-
ated with active smoking is estimated to be 2.2 .
In India, a large survey has concluded that up to
half of all TB deaths can be attributed to smoking
. These date were confirmed by a prospective
Some studies have also concluded that the
severity of disease, the speed of bacteriological
conversion and the rate of failure and relapse may
be negatively influenced by smoking .
Public Health impact of smoking
among TB patients
Smoking has a large impact on public health,
due to the increase in risk of several severe and po-
tentially lethal diseases. It appears therefore that
the increase in smoking habit is not only the cause
of an increase in the prevalence of COPD [23, 24]
but also of tuberculosis. Considering the large and
increasing number of smokers in many developing
countries which also experience a high burden of
tuberculosis, the population attributable risk is
now considered to be significant . A recent
evaluation by WHO has come to the conclusions
that up to 16% of cases of tuberculosis in low-in-
come countries and 28% in high-burden countries
could be attributed to smoking . The associa-
tion between smoking and tuberculosis may be
even higher in populations with a large proportion
of HIV infection .
One of the intriguing questions is to know why
it has taken so long to realize the interaction be-
tween smoking and tuberculosis. One of the rea-
sons may be the fact that smoking was considered
a health problem mainly in developed countries
with a low burden of tuberculosis, whereas devel-
oping countries with a high burden of tuberculosis
had until recently a low or moderate prevalence of
smoking. One notable exception is Eastern Europe,
where the prevalence of both smoking and tubercu-
losis is high. Considering the increase in smoking
habits of the countries with the highest burden of
TB, this interaction can no more be ignored.
The practical consequence for all health care
workers active in the management of tuberculosis
is the clear obligation to address the problem of
smoking with all patients under treatment for tu-
berculosis and to advise the smokers to stop smok-
ing. In order to achieve this, training of health care
workers has to be provided. A study has demon-
strated the impact of minimal advice in such set-
tings . Patients treated by trained health care
workers have a greater chance of stopping smok-
ing at the end of the treatment of tuberculosis than
patients treated by untrained health care profes-
sionals. Tobacco cessation has to be included in
standard practice for all caregivers engaged in the
management of tuberculosis .
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