The changing face of HIV in China.

Yunnan Center for Disease Control and Prevention, Yunnan, People's Republic of China.
Nature (Impact Factor: 42.35). 11/2008; 455(7213):609-11. DOI: 10.1038/455609a
Source: PubMed

ABSTRACT HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread?

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    ABSTRACT: To investigate the molecular subtypes of prevalent HIV-1 strains and characterize the genetics of dominant strains among men who have sex with men. Molecular epidemiology surveys in this study concentrated on the prevalent HIV-1 strains in Liaoning province by year. 229 adult patients infected with HIV-1 and part of a high-risk group of men who have sex with men were recruited. Reverse transcription and nested PCR amplification were performed. Sequencing reactions were conducted and edited, followed by codon-based alignment. NJ phylogenetic tree analyses detected two distinct CRF01_AE phylogenetic clusters, designated clusters 1 and 2. Clusters 1 and 2 accounted for 12.8% and 84.2% of sequences in the pol gene and 17.6% and 73.1% of sequences in the env gene, respectively. Another six samples were distributed on other phylogenetic clusters. Cluster 1 increased significantly from 5.6% to 20.0%, but cluster 2 decreased from 87.5% to 80.0%. Genetic distance analysis indicated that CRF01_AE cluster 1 in Liaoning was homologous to epidemic CRF01_AE strains, but CRF01_AE cluster 2 was different from other scattered strains. Additionally, significant differences were found in tetra-peptide motifs at the tip of V3 loop between cluster 1 and 2; however, differences in coreceptor usage were not detected. This study shows that subtype CRF01_AE strain may be the most prevalent epidemic strain in the men who have sex with men. Genetic characteristics of the subtype CRF01_AE cluster strain in Liaoning showed homology to the prevalent strains of men who have sex with men in other parts of China. J. Med. Virol. 87:557-568, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
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    ABSTRACT: Background This study described knowledge about HIV prevention and transmission among labor migrants in China and assessed the factors that associate with HIV knowledge. Methods The study is based on primary data collected in Xi’an city, China. The study includes 939 male rural-to-urban migrants aged 28 and older. The multivariate analysis used OLS regression techniques to examine the correlates of HIV knowledge. Results Most migrants know what AIDS/HIV is, but many have deficient knowledge about self-protection and the transmission routes of HIV. About 40% of migrants fail to understand that condoms decrease the risk of HIV infection. Higher levels of education and internet usage associate with better HIV knowledge. Migrants who have engaged in sex with commercial sex workers have better HIV knowledge than migrants who have never paid for sex. This includes better knowledge of self-protection. Conclusion Labor migrants are a high risk population for HIV infection. Their lack of HIV knowledge is a serious concern because they are a vulnerable group for infection and their sexual behaviors are spreading HIV to other members of the population and across geographic areas.
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