Success with antiretroviral treatment for children in Kigali, Rwanda: Experience with health center/nurse-based care

Médecins Sans Frontières, Kigali, Rwanda.
BMC Pediatrics (Impact Factor: 1.93). 10/2008; 8(1):39. DOI: 10.1186/1471-2431-8-39
Source: PubMed


Although a number of studies have shown good results in treating children with antiretroviral drugs (ARVs) in hospital settings, there is limited published information on results in pediatric programs that are nurse-centered and based in health centers, in particular on the psychosocial aspects of care.
Program treatment and outcome data were reported from two government-run health centers that were supported by Médecins Sans Frontières (MSF) in Kigali, Rwanda between October 2003 and June 2007. Interviews were held with health center staff and MSF program records were reviewed to describe the organization of the program. Important aspects included adequate training and supervision of nurses to manage ARV treatment. The program also emphasized family-centered care addressing the psychosocial needs of both caregivers and children to encourage early diagnosis, good adherence and follow-up.
A total of 315 children (< 15 years) were started on ARVs, at a median age of 7.2 years (range: 0.7-14.9). Sixty percent were in WHO clinical stage I/II, with a median CD4% of 14%. Eighty-nine percent (n = 281) started a stavudine-containing regimen, mainly using the adult fixed-dose combination. The median follow-up time after ARV initiation was 2 years (interquartile range 1.2-2.6). Eighty-four percent (n = 265) of children were still on treatment in the program. Thirty (9.5%) were transferred out, eight (2.6%) died and 12 (3.8%) were lost to follow-up. An important feature of the study was that viral loads were done at a median time period of 18 months after starting ARVs and were available for 87% of the children. Of the 174 samples, VL was < 400 copies/ml in 82.8% (n = 144). Two children were started on second-line ARVs. Treatment was changed due to toxicity for 26 children (8.3%), mainly related to nevirapine.
This report suggests that providing ARVs to children in a health center/nurse-based program is both feasible and very effective. Adequate numbers and training of nursing staff and an emphasis on the psychosocial needs of caregivers and children have been key elements for the successful scaling-up of ARVs at this level of the health system.

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Available from: Johan van Griensven, Oct 01, 2015
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    • "This provides further impetus to the urgency of ensuring that children in resource-limited settings have early access to life-prolonging ART. Virological evidence is an advantage in assessing therapeutic responses [18]. In this study, the mean baseline VL decreased to below the LOQ after three months of ART. "
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    BMC Research Notes 07/2014; 7(1):419. DOI:10.1186/1756-0500-7-419
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    • "The CHBC model therefore stands to improve child survival greatly if ART is initiated early. Furthermore, patients can benefit from ancillary interventions to promote health and well-being such as food supplements, adherence counselling, and psychosocial support also effective only if retained in the programmes [34–36]. Of note, the CHBC and FBFCA models reach two different populations of HIV-infected children (Table 1). "
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    04/2014; 2014:852489. DOI:10.1155/2014/852489
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    • "According to WHO, task shifting is a " process whereby specifi c tasks are moved, wherever appropriate, to health workers with shorter training… task shifting can make more effi cient use of existing human resources and ease bottlenecks in service delivery " (Chan 2008: 7). For example, in Botswana and Rwanda, task shifting to nurses was developed as a promising strategy to scale up and sustain adult and paediatric antiretroviral treatments, particularly where provider shortages threatened ART rollout (Griensven et al 2008; Monyatsi et al 2011). "
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