Article

L-selectride-mediated highly diastereoselective asymmetric reductive aldol reaction: access to an important subunit for bioactive molecules.

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Organic Letters (Impact Factor: 6.14). 11/2008; 10(21):4811-4. DOI:10.1021/ol801971t
Source: PubMed

ABSTRACT L-selectride reduction of a chiral or achiral enone followed by reaction of the resulting enolate with optically active alpha-alkoxy aldehydes proceeded with excellent diastereoselectivity. The resulting alpha,alpha-dimethyl-beta-hydroxy ketones are inherent to a variety of biologically active natural products.

0 0
 · 
0 Bookmarks
 · 
124 Views

Full-text (2 Sources)

View
19 Downloads
Available from
Sep 12, 2013